Effects of Bovine α-Lactalbumin on Gastric Defense Mechanisms in Naive Rats(Food & Nutrition Science)
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概要
- 論文の詳細を見る
We recently investigated the effects of the major proteins in cow's milk on gastric mucosal injuries in rat ulcer models. We found that α-lactalbumin (α-LA) has marked preventive effects against gastric mucosal injuries and that prostaglandin (PG) synthesis may contribute to these effects [Matsumoto et al., Biosci. Biotechnol. Biochem., 65, 1104-1111, 2001]. In this study, we investigated the effects of α-LA on several defense mechanisms of gastric mucosa by evaluating gastric PGE_2 content, gastric mucin content, gastric luminal pH, gastric fluid volume, and gastric emptying in naive rats. Oral administration of α-LA (200, 500, and 1000 mg/kg) elevated endogenous PGE_2 levels in gastric tissue and increased the gastric mucin contents of both the gastric fluid and the adherent mucus gel layer. In addition to these PG-related responses, α-LA also caused PG-independent responses such as elevation of gastric luminal pH, increase in gastric fluid volume, and delay in gastric emptying. These responses were observed to be dose-dependent (200-1000 mg/kg of α-LA). Thus, we demonstrated that α-LA enhances both PG-dependent and PG-independent gastric defense mechanisms in naive rats. Both of these mechanisms are probably involved in its gastroprotective action.
- 社団法人日本農芸化学会の論文
- 2003-03-23
著者
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Ushida Y
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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TOIDA Tomohiro
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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Toida Tomohiro
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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SHIMOKAWA Yukiko
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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HAYASAWA Hirotoshi
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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MATSUMOTO Hiroshi
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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Hayasawa Hirotoshi
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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Hayasawa Hirotoshi
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd. :biochemical Research Laboratory Mori
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USHIDA Yoshihiko
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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Shimokawa Y
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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Shimokawa Yukiko
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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Matsumoto H
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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Toida Tomohiro
Food Sci. & Technol. Inst. Morinaga Milk Ind. Co. Ltd.
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