New Biological Function of Bovine α-Lactalbumin : Protective Effect against Ethanol- and Stress-induced Gastric Mucosal Injury in Rats

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概要

• 論文の詳細を見る

• Although several studies have shown that milk protein components have a wide range of biological activities, the potential role of these proteins in the gastrointestinal mucosal defense system is less well elucidated. In this study, we investigated the effect of the major proteins in cow's milk on gastric mucosal injury by using two acute ulcer models in Wistar rats. Gastric mucosal injury was induced by either intragastric 60% ethanol-HCl or water-immersion restraint stress (23℃, 7h). Each test milk protein was orally administered 30 min before the induction of gastric injury. Among the major milk proteins, α-lactalbumin (α-LA) is demonstrated to have a marked protective effect against ethanol-induced gastric injury, with the same potency as that of the typical antiulcer agent, Selbex. Whey protein isolate (WPI), which contained 25% α-LA, also protected against gastric injury, while casein showed no effect. Comparative studies on the protective effect of the four major components of WPI, β-lactoglobulin, α-LA, bovine serum albumin and γ-globulins (immunoglobulins), on the basis of their contents in WPI revealed that α-LA was responsible for the protective effect of WPI, being about 4-fold more effective than WPI itself. α-LA showed dosedependent protection against gastric injury induced by stress as well as ethanol. Pretreatment with indomethacin (10 mg/kg body weight, s.c.), which is a potent inhibitor of endogenous prostaglandin synthesis, resulted in a significant reduction in the protective effect of α-LA. These results indicate that α-LA has marked antiulcer activity as an active component of cow's milk protein, and suggest that α-LA intake may serve to protect against gastric mucosal injury, in part through endogenous prostaglandin synthesis.

• 社団法人日本農芸化学会の論文
• 2001-05-23

著者

• Ushida Y

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• TOIDA Tomohiro

  Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.

• Toida Tomohiro

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• SHIMOKAWA Yukiko

  Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.

• HAYASAWA Hirotoshi

  Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.

• MATSUMOTO Hiroshi

  Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.

• Hayasawa Hirotoshi

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• Hayasawa Hirotoshi

  Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd. :biochemical Research Laboratory Mori

• USHIDA Yoshihiko

  Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.

• Shimokawa Y

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• Shimokawa Yukiko

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• Matsumoto H

  Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.

• Toida Tomohiro

  Food Sci. & Technol. Inst. Morinaga Milk Ind. Co. Ltd.

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