Antitumor Activity of Phenylahistin in Vitro and in Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC_<50> values ranging from 1.8×10^<-7> to 3.7×10^<-6>, while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.
- 社団法人日本農芸化学会の論文
- 1999-06-23
著者
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KANOH Kaneo
Marine Biotechnology Institute Co. Ltd.
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Kanoh Kaneo
Shimizu Laboratories Marine Biotechnology Institute
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Katada Jun
Life Science Research Center Advanced Technology Research Laboratories Nippon Steel Corporation
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HAYASHI Yoshio
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation
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KANOH Kaneo
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation
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KOHNO Shinkichi
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation
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UNO Isao
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation
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MURAMATSU Michiko
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation
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Uno I
Life Science Research Center Advanced Technology Research Laboratories Nippon Steel Corporation
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Uno Isao
Life Science Research Center Advanced Technology Research Laboratories Nippon Steel Corporation
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Kohno Shinkichi
Life Science Research Center Advanced Technology Research Laboratories Nippon Steel Corporation
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Kito Keijiro
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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Muramatsu M
Life Science Research Center Advanced Technology Research Laboratories Nippon Steel Corporation
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Yamaguchi H
Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr
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