Scavenging Effect of Various Tea Extracts on Superoxide Derived from the Metabolism of Mutagens

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We determine the superoxide formed in the self-degradation of mutagens activated by cytochrome enzymes and evaluated the scavenging effect of various tea extracts. Benzo[a]pyrene (B[a]P) and 2-amino-6-methyldipyrido (1,2-a : 3', 2'-d) imidazole (Glu-P-1) each produced a large amount of superoxide after activation by cytochrome enzymes. However, 2-amino-3-methyl-imidazo (4,5-f) quinoline (IQ), 3-amino-1,4-dimethyl-5H-pyridol (4,3-b) indole (Trp-P-1) and alfatoxin B_1 (AFB_1) failed to generate a significant amount of superoxide. The addition of a tea extract to the reaction system marked inhibited the derivation of superoxide from Glu-P-1. However, the tea extracts showed weaker inhibition of the B[a]P-mediated formation of superoxide. Among the four teas tested, the oolong tea extract tended to exhibit the strongest inhibitory effect. Our results suggest that the chemopreventive efficacy of a tea extract is partly associated with its antioxidative activity.
社団法人日本農芸化学会の論文
1998-09-23