Suppressive Effects of Lactoferrin on Bleomycin-dependent DNA Damage by the Iron Ion and Ascorbate
スポンサーリンク
概要
- 論文の詳細を見る
The effects of the iron ion and reductones on bleomycin (BLM)-induced DNA degradation were observed by measuring the amount of malondialdehyde (MDA) formed. The formation of MDA was detected after adding Fe^<2+> or Fe^<3+> + Asc combined to a solution consisting of DNA and BLM, but not after adding Fe^<3+> alone, catecholamines or phenolic compounds. Marked suppressive effects of lactoferrin (Lf) and ovotransferrin on MDA formation were observed in the solution with Fe^<2+> or Asc. However, serum albumin, β-lactoglobulin, α-lactalbumin, and ovoalbumin had no effect on suppressing MDA formation. The suppression by bovine Lf (bLf) of MDA formation decreased with increasing iron saturation at 1.0mM Fe^<2+>, but at 100% iron saturation, 51.2% of apo-bLf remained suppression. In the solution with 0.25mM Asc, 100% iron saturated bLf markedly enhanced MDA formation.
- 社団法人日本農芸化学会の論文
- 1994-01-23
著者
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TOMITA Shinichi
Department of Agricultural Chemistry, Tamagawa University
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KIYOSAWA Isao
Department of Agricultural Chemistry, Tamagawa University
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Matuyama Jun
Department Of Agricultural Chemistry Tamagawa University
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Kiyosawa I
Department Of Agricultural Chemistry Tamagawa University
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Kiyosawa Isao
Department Of Agricultural Chemistry Faculty Of Agriculture Tamagawa University
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Tomita Shinichi
Department Of Agricultural Chemistry Tamagawa University
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Nyui S
Tamagawa Univ. Tokyo Jpn
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Nyui Shoko
Department Of Agricultural Chemistry Tamagawa University
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Matsue Mutsumi
Department of Agricultural Chemistry, Tamagawa University
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Matsue Mutsumi
Department Of Agricultural Chemistry Tamagawa University
関連論文
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- Agglutination of Bacterial Cells of Clostridium innocuum, Bifidobacterium longum, and Micrococcus luteus by Lactoferrin and Ovotransferrin
- Suppressive Effects of Lactoferrin on Bleomycin-dependent DNA Damage by the Iron Ion and Ascorbate
- Binding of Lactoferrin to Bacterial Cells of the Clostridium Species and Their Agglutination
- Interaction of Lactoferrin with Ascorbate and the Relationship with Bleomycin-Dependent DNA Damage
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