Rationale and Design of a Large-Scale Trial Using Nicorandil as an Adjunct to Percutaneous Coronary Intervention for ST-Segment Elevation Acute Myocardial Infarction : Japan-Working Groups of Acute Myocardial Infarction for the Reduction of Necrotic Damag

スポンサーリンク

概要

• 論文の詳細を見る

• Background The benefits of percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) are limited by reperfusion injury. In animal models, nicorandil, a hybrid of an ATP-sensitive K^+ (KATP) channel opener and nitrates, reduces infarct size, so the Japan-Working groups of acute myocardial Infarction for the reduction of Necrotic Damage by a K-ATP channel opener (J-WIND-KATP) designed a prospective, randomized, multicenter study to evaluate whether nicorandil reduces myocardial infarct size and improves regional wall motion when used as an adjunctive therapy for AMI. Methods and Results Twenty-six hospitals in Japan are participating in the J-WIND-KATP study. Patients with AMI who are candidates for PCI are randomly allocated to receive either intravenous nicorandil or placebo. The primary end-points are (1) estimated infarct size and (2) left ventricular function. Single nucleotide polymorphisms (SNPs) that may be associated with the function of KATP-channel and the susceptibility of AMI to the drug will be examined. Furthermore, a data mining method will be used to design the optimal combined therapy for post-myocardial infarction (MI) patients. Conclusions It is intended that J-WIND-KATP will provide important data on the effects of nicorandil as an adjunct to PCI for AMI and that the SNPs information that will open the field of tailor-made therapy. The optimal therapeutic drug combination will also be determined for post-Mi patients.

• 社団法人日本循環器学会の論文
• 2004-01-20

著者

• Kitakaze Masafumi

  Cardiovascular Div. Of Medicine National Cardiovascular Center

• Asanuma Hiroshi

  Department of Cardiology, National Cardiovascular Center

• KIM Jiyoong

  Cardiovascular Division of the Department of Medicine, National Cardiovascular Center

• Kim Jyonjoon

  Cardiovascular Division Of Medicine National Cardiovascular Center

• Kim Jiyoong

  Department Of Cardiology National Cardiovascular Center

• Minamino Tetsuo

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Shintani Yasunori

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• Shintani Yasunori

  Osaka University

• Kimu Jiyoong

  国立循環器病センター

• Asanuma Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Minamino Tetsuo

  Research Resident of Japan Foundation for Aging and Health for Medical Frontier Strategy Research by

• Asakura Masanori

  Japan Society for the Promotion of Sciencefor Young Scientists

• Kim Jiyoong

  Cardiovascular Division of Medicine, National Cardiovascular Center

関連論文

• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• PJ-372 Systemic Vascular Resistance Guided Optimal Drug Selection in Patients with Acute Decompensated Heart Failure : A Validation Study(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PE-113 Differences in Dyssynchrony Based on Time-to-peak Velocity, Displacement, Strain and Strain Rate(PE019,Echo/Doppler (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OJ-141 Relationship between Aortic Valve Area and Pressure Gradient : Impact of Transvalvular Flow Rate on Assessment of Aortic Stenosis(OJ24,Echo/Doppler (Others) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• Inhibition of Cardiac Remodeling by Pravastatin Is Associated with Amelioration of Endoplasmic Reticulum Stress
• Plasma Adiponectin Is Associated with Plasma Brain Natriuretic Peptide and Cardiac Function in Healthy Subjects
• PJ-308 Miglitol, a Novel Alpha-Glucosidase Inhibitor, Improves Left Ventricular Function in Dogs With Pacing-Induced Heart Failure(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-091 Activation of AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• Atorvastatin Slows the Progression of Cardiac Remodeling in Mice with Pressure Overload and Inhibits Epidermal Growth Factor Receptor Activation
• Long-Term Oral Administration of Dipyridamole Improves Both Cardiac and Physical Status in Patients with Mild to Moderate Chronic Heart Failure : A Prospective Open-Randomized Study
• Impact of Adenosine Receptor Signaling and Metabolism on Pathophysiology in Patients with Chronic Heart Failure
• 3 ST2 is an Emerging Functional Biomarker Predicting Mortality after Acute Heart Events and Comprising Stress-induced Cardioprotective Signaling System with IL-33(Biomarkers, Genetic Polymorphism, and Risk Estimation,Symposium 1 (SY-01) (H),The 73rd Annua
• An infantile case of Hinman syndrome with severe acute renal failure
• Dorsal inlay graft urethroplasty for primary hypospadiac repair
• Changing concepts in urological management of the congenital anomalies of kidney and urinary tract, CAKUT
• I-27 LONG-TERM UROLOGICAL MANAGEMENT OF CLOACAL ANOMALIES
• Inflammatory pseudotumor of the bladder in neonates
• Congenital vesticovaginal fistula
• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• PE-055 The Clinical Value of Novel Endocardial Circumferential Strain Assessed from Myocardial Speckle-Tracking Imaging in Patients with Hypertension(Echo/Doppler-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-048 Development of New Parenteral Inotrope : β_2 Adrenergic Agonist in Sticky Tape-form(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-016 Left Atrial Volume Mirrors Diastolic Dysfunction Caused by Hypertension Alone(Echo/Doppler-14 (I) PJ3,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-390 The Plasma Adiponectin Independently Correlates with Both Brain Natriuretic Peptide and Transmitral Flow Pattern Revealed in the Japanese Cohort Study(Heart failure, clinical-6 (M) OJ65,Oral Presentation (Japanese),The 70th Anniversary Annual Scien
• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• OJ-390 The Plasma Adiponectin Independently Correlates with Both Brain Natriuretic Peptide and Transmitral Flow Pattern Revealed in the Japanese Cohort Study(Heart failure, clinical-6 (M) OJ65,Oral Presentation (Japanese),The 70th Anniversary Annual Scien
• 2 Multiple Roles of Adiponectin from the Progression of Coronary Atherosclerosis to the Ventricular Remodeling and Heart Failure(New Horizons in the Metabolic Syndrome:-Molecular Mechanisms and Therapies,Plenary Session 4 (PL4) (H),The 70th Anniversary An
• PJ-047 The Combined Therapy of Angiotensin Converting Enzyme Inhibitor, Angiotensin II Receptor Blocker and Beta-blockers Submaximally Limits Infarct Size(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
• PJ-046 Celiprolol, a Selective β_1-Adrenoceptor Antagonist, Limits Infarct Size via NO-dependent Mechanisms(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
• Abnormal Glucose Tolerance Contributes to the Progression of Chronic Heart Failure in Patients with Dilated Cardiomyopathy
• 3 Human Atrial Natriuretic Peptide and Nicorandil as an Adjunct to Reperfusion Therapy for Acute Myocardial Infarction : Lessons from J-WIND Trials(Discovery of Adjunctive Therapies for Acute Myocardial Infarction-From Bench to Bedside-, The 71st Annual S
• Dobutamine Stress Echocardiography Unmasks Acute Worsening of Mitral Regurgitation with Latent Left Ventricular Outflow Tract Obstruction Behind Diastolic Heart Failure in Hypertensive Heart Disease
• PE-050 Subendocardial and Subepicardial Radial Strain in Ischemic Heart Disease Assessed with a Novel Two-Dimensional Ultrasound Speckle Tracking Imaging(Echo/Doppler-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-119 Cardiac Rotation as a Possible Compensatory Mechanism for Decreased Radial Strain During Dobutamine Stress Echocardiography(Recent Advance in Echocardiography-2 (I) FRS24,Featured Research Session (English),The 70th Anniversary Annual Scientific M
• FRS-079 Prevalence of Diastolic Left Ventricular Dysfunction in Asymptomatic Residents in Japanese Community(Clinical Heart Failure, Diagnosis and Treatment-1 (M) FRS16,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of
• PE-276 Influence of Dynamic Exercise on Severity of Functional Mitral Regurgitation in Patients with Idiopathic Dilated Cardiopmyopathy(Valvular heart disease/Pericarditis/Cardiac tumor-2, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• The ATP-sensitive Potassium Channel Opener, Nicorandil, Reduces No-reflow Phenomenon and Infarct Size in the Canine Heart
• Adenosine-Induced Cardiac Gene Expression of Ischemic Murine Hearts Revealed by cDNA Array Hybridization
• Polymyxin B-immobilized fiber may improve hemodynamics in patients with severe sepsis and septic shock via the attenuation of nitric oxide
• PE-311 Influence of Metabolic Syndrome Risk Factors on Left Ventricular Diastolic Dysfunction : Assessed with Left Atrial Size and Tissue Doppler Imaging(Diabetes/Obesity/Metabolic syndrome(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting
• FRS-027 Diastolic Untwisting is Delayed in Chronic Mitral Regurgitation(Recent Advance in Echocardiography-1 (I) FRS6,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PE-060 Echocardiographic Signs of Pericardial Constriction as Predictors of Maternal Heart Failure in pregnant Women after Open Heart Surgery(Echo/Doppler-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-234 Plasma level of BMP but not systolic BP becomes a predictive marker of left ventricular hypertrophy in community screening(Preventive Medicine/Epidemiology/Education 2 (H) : OE29)(Oral Presentation (English))
• PJ-416 Could Low Dose Carperitide Improve Left Ventricular Diastolic Dysfunction in Idiopathic Dilated Cardiomyopathy? Validation with Tissue Doppler Imaging(Heart failure, clinical-13 (M) PJ70,Poster Session (Japanese),The 70th Anniversary Annual Scienti
• PJ-092 Activation of Adenosine A1 Receptors Inhibits Aldosterone Synthesis in Adrenal Glands(Metabolism/Biochemistry/Energetics-3 (M) PJ16,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Angiotensin II Type 1 Receptor Blocker Prevents Atrial Structural Remodeling in Rats with Hypertension Induced by Chronic Nitric Oxide Inhibition
• 2 How to Find Novel Pathophysiology and Therapy of Chronic Heart Failure from Genomic Database(Perspectives of Genome-wide Study to Identify Genes Underlying Cardiovascular Diseases,Roundtable Discussion 10 (RT10) (M),The 70th Anniversary Annual Scientifi
• Asymmetrical Dimethyl Arginine (ADMA) is a Novel Marker of Coronary Stent Restenosis
• OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
• OJ-324 Antagonism of Aldosterone Receptor Attenuates Severity of Cardiac Dysfunction and Inflammation Induced by Chronic Blockade of NO Synthesis in Rats(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Japanese))
• Canine DNA Array as a Potential Tool for Combining Physiology and Molecular Biology : An Application for the Gene Expression Profile of Regional Ischemic Myocardium
• An Adenosine Analogue, Chloroadenosine, Attenautes Pressure-Overload Myocardial Hypertrophy in Mice
• The New Metalloproteinase Inhibitor Blocks Cardiac Hypertrophy Induced by both Phenylephrine and Angiotensin II
• New Therapeutic Application of Erythropoietin Against Ischemic Heart Diseases
• OJ-320 Granulocyte Colony-Stimulating Factor Mediates Cardioprotection against Ischemia/Reperfusion Injury via Phosphatidylinositol-3-Kinase/Akt Pathway : Evaluation in Vitro Cardiomyocytes and in Vivo Canine Hearts(Acute myocardial infarction, basic-2 (I
• The Pathophysiological Role of Endoplasmic Reticulum Stress in the Failing Hearts : Possibility of Brain-Type Natriuretic Peptide as its Marker (Heart Failure, Basic 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Selective Blockade of Serotonin 5HT2A Receptor Increases Coronary Blood Flow via NO-Dependent Pathway Through 5HT1B Receptor in Hypoperfused Canine Hearts(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Cir
• Nongenomic Deleterious Effects of Aldosterone on Ischemic Hearts via PKC-Dependent Pathway in Dogs(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Decreased Proteasome Activity by Oxidative Stress Induces Cardiac Myocytes Apoptosis via p53-mediated Pathway(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-271 Reduced Systolic Strain and Systolic Strain Rate Could Detect Sub-clinical Acute Rejection in Heart Transplant Recipients(Transplantation/LVAD-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Laparoscopy Assisted Orchiopexy : Technical Feasibility and Indications
• Coordinate Induction of AMP Catabolic Enzymes in Human Atrial Myocytes with Mitochondrial DNA Deletion : Novel Mechanism on Biochemical Atrial Remodeling
• Carperitide and Adiponectin : How Are They Connected Each Other to Benefit Acute Decompensated Heart Failure?
• Fabrication of Nickel Based Active Composites
• 433 Fabrication of Nickel Based Active Composites
• Hypothetical Mechanism of the Improvement by Adaptive Servo-Ventilation of the Pathophysiology of Heart Failure Associated With Sleep-Disordered Breathing
• 2 Acidosis Reperfusion Affords Cardioprotection via Inhibition of Na^+-H^+ and Na^+-Ca^ exchanges against Ischemia and Reperfusion Injury(Pharmacological Intervention for Coronary Artery Disease,Symposium 2 (SY2) (IHD),The 70th Anniversary Annual Scie
• Data Mining of the Best Treatments of Chronic Heart Failure and Proposal of Adenosine Therapy as a New Treatment
• PE-541 Glycosaminoglycan Modification of Neuropilin-1 Modulates VEGFR2 Signaling(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-126 The Direct Physiological Impact of C-reactive Protein on Ischemicin Vivo Hearts : Reduced Cardiac Nitric Oxide Production but Saved Metabolization(Coronary Circulation, Basic/Clinical 2 (IHD) : OE15)(Oral Presentation (English))
• Differential Effect on Acute Cardioprotection against Myocardial Infarction by Statins : Role of ECTO-5'-Nucleotidase
• Preischemic Protein Kinase-A Activation Triggers Cardioprotection of Ischemic Preconditioning via the Inhibition of Rho-Kinase
• The Simple and Accurate Method to Identify Early Ventricular Contraction Sites in Wolff-Parkinson-White Syndrome by High Frame-Rate Tissue Velocity Imaging
• Quantitative Assessment of Wall Motion Using Myocardial Strain
• Rationale and Design of a Large-Scale Trial Using Nicorandil as an Adjunct to Percutaneous Coronary Intervention for ST-Segment Elevation Acute Myocardial Infarction : Japan-Working Groups of Acute Myocardial Infarction for the Reduction of Necrotic Damag
• Rationale and Design of a Large-Scale Trial Using Atrial Natriuretic Peptide (ANP) as an Adjunct to Percutaneous Coronary Intervention for ST-Segment Elevation Acute Myocardial Infarction : Japan-Working Groups of Acute Myocardial Infarction for the Reduc
• HB-EGF Is an Essential Growth Factor for Cardiomyocyte Metabolism : The Possibility for a Novel Therapeutic Target for Heart Failure
• Preischemic Protein Kinase-A Activation Evokes Ischemic Preconditioning through Rho-Kinase Inhibition Independent of Protein Kinase-C : A Novel Mechanism
• Medical Health Care Checkup Reveals a Novel Risk Factor of Diastolic Heart Dysfunction : Impact of Impaired Glucose Tolerance(Cardiovascular Disease Risk in Diabetes and Glucose Intolerance, The 69th Annual Scientific Meeting of the Japanese Circulation S
• 2 Systematic Linkage between the Genomic and Clinical Database of Cardiovascular Disease to Find New Pathophysiology or Effective Treatment(Symposium 5 (SY5) (IHD) : Genome Informatics of Cardiovascular System)(Special Program)
• 5 A new strategy for fishing individual risk factors of life-style related disease in lifestyle, biochemical data and genomics in Nishiarita(Plenary Session 7 (PL7) (H) : Health Promotion Act and Cardiovascular Disease Prevention)(Special Program)
• Quantitative Assessment of Regional Contraction Using Newly Developed Angle-Corrected Color Strain Imaging System
• Carvedilol Treatment Prevents the Attenuation of Left Ventricular Contractile Response to Dobutamine in Patients with Dilated Cardiomyopathy
• OJ-298 MEKK1 is Required in Vascular Remodeling after Injury in Carotid Ligation Model(Restenosis after Angioplasty, Basic/Clinical 2 (IHD) : OJ36)(Oral Presentation (Japanese))
• PJ-530 Fasting Serum Phosphate Level : A Potential Marker of Visceral, but not Subcutaneous, Fat Area(Kidney/Renal circulation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 2 Statin Prevents Structural and Electrical Atrial Remodeling in Rat Hypertensive Heart Failure Induced by Chronic Inhibition of Nitric Oxide Synthesis(Heart Failure and Arrhythmia, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Vinegar Intake Enhances Flow-Mediated Vasodilatation via Upregulation of Endothelial Nitric Oxide Synthase Activity
• Management and Two-Year Long-Term Clinical Outcome of Acute Coronary Syndrome in Japan:– Prevention of AtherothrombotiC Incidents Following Ischemic Coronary Attack (PACIFIC) Registry –
• Impact of Physical Activity on Cardiovascular Events in Patients With Chronic Heart Failure:– A Multicenter Prospective Cohort Study –
• A Successful Case of Percutaneous Transluminal Septal Myocardial Ablation for Mitral Regurgitation that Emerged Following Mitral Valve Repair Surgery
• Management and Two-Year Long-Term Clinical Outcome of Acute Coronary Syndrome in Japan : Prevention of AtherothrornbotiC Incidents Following Ischemic Coronary Attack (PACIFIC) Registry
• Dynamic changes in plasma total and high molecular weight adiponectin levels in acute heart failure

もっと見る 閉じる

スポンサーリンク