Multiple endothelial injury in epicardial coronary artery induces downstream microvascular spasm through oxygen free radical and endothelin-1

スポンサーリンク

概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2002-03-31

著者

• Saitoh Shuichi

  First department of internal medicine, Fukushima Medical University

• Murai Kazunori

  岩手医科大学 病理学

• Matsumoto Ken

  First Department of Internal Medicine, Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  First Depertment of Internal Medicine, Fukushima Medical University

• Osugi Taku

  First Department Of Internal Medicine Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical College

• Saitoh Shuichi

  First Department Of Internal Medicine Fukushima Medical University

• Matsumoto Ken

  First Department Of Internal Medicine Fukushima Medical University

• Murai Kazunori

  Department Of Internal Medicine Hematology/oncology Iwate Medical University School Of Medicine

• Saitoh Shuich

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  Department Of Internal Medicine Hematology/oncology Iwate Medical University School Of Medicine

• Maehara Kazuhira

  First Department Of Internal Medicine Fukushima Medical University

• Saitoh Shu-ichi

  First Department Of Internal Medicine Fukushima Medical University

• Muto Mitsuru

  First Department of Internal Medicine, Fukushima Medical University

• Aikawa Kazuhiko

  First Department of Internal Medicine, Fukushima Medical University

• Maehara Kaztuhira

  First Department Of Internal Medicine Fukushima Medical University

• Muto Mitsuru

  First Department Of Internel Medicine Fukushima University Of Medicine

• Yui Mitsuru

  Department Of Cardiology Iwaki Kyoritsu General Hospital

• Muto Mitsuru

  First Department Of Internal Medicine Fukushima Medical University

• Aikawa Kazuhiko

  First Department Of Internel Medicine Fukushima University Of Medicine

• Saitoh Shunichi

  The First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  福島県立医科大学 第1内科

• Saitoh Shuichi

  The First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  Internal Medicine Shirakawa Kousei Hospital

• Murai Kazunori

  Department Of Hematology/oncology Internal Medicine Iwate Medical University

• Maehara Kazuhira

  First Department Of Internal Medicine

関連論文

• OE-296 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Adenosine 5'-diphosphate, and Angiotensin(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific M
• Attenuation of Cardioprotective Effect by Postconditioning in Coronary Stenosed Rat Heart and Its Restoration by Carvedilol
• PJ-294 Quantitative Analysis of Change in Early Diastolic Strain Rate for Exercise Induced Myocardial Ischemia: Comparison with TC^ Myocardial Scintigraphy(Echo/Doppler(14)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PE-533 Short-term Cholesterol-lowering Therapy Improves Myocardial Microvascular Dysfunction in Patients with Hypercholesterolemia : Evaluation of Myocardial Blood Velocity by Myocardial Contrast Echocardiography(Echo/Doppler(10)(I),Poster Session(English
• PE-388 Atorvastatin Blocks an Advanced Glycation End Products (AGE) : Receptor for AGE(RAGE) Axis in Diabeteic Vascular Responses(Cardiovascular pharmacology, basic/clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
• PE-086 New Insights into Oxidized LDL-induced RhoA and Rac1 Activation by an LOX-1-MT1-MMP Axis in Endothelial Dysfunction(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-248 New Developed Powerful Tool for Detecting of Exercise Induced Myocardial Dysfunction : Assessment of Early Diastolic Strain Rate(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
• Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis
• Prediction of Remote Left Ventricular Volumes and Functions After Acute Myocardial Infarction With Successful Coronary Intervention
• DPJ-072 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha1-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(DPJ12,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Digital Poster Session (Japanese),The 73rd
• Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes
• Unexpected Worsening of Mitral Regurgitation After Surgical Closure of Atrial Septal Defect
• Involvement of von Willebrand Factor and PGI_2 in Platelet Binding to a Partially Denuded Endothelial Monolayer
• PJ-664 LOX-1 plays a crucial role in RhoA-and Rac1-dependent signaling through Gi induced by oxidized low-density lipoprotein in endothelial cells(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-559 Pravastatin Rapidly Prevents Thrombin-induced Vasoconstriction and NADPH Oxidase-dependent ROS Generation in vivo : Implications for Beneficial Effect(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese
• PJ-216 Receptor for Advanced Glycation End Products (RAGE) Plays a Crucial Role in Atherosclerosis(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-067 New Insights into Regulation of Diabetic Vascular Remodeling by an MT1-MMP-RAGE axis(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-197 RhoA-Dependent PAI-1 Gene Exprssion Induced in Endothelial Cells by Monocyte Adhesion is Mediated Via Geranylgeranyl Transferase I and Ca^ Signaling(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-475 Crucial Role of Geranylgeranyl Transferase I in AGE-Induced Gene Expression in Diabetes(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-473 A Novel Role of LOX-1 in Monocyte Adhesion-Induced Gene Expression via Redox-Sensitive and Ca^ Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
• PJ-102 MT1-MMP-RAGE Axis in Regulation of Advanced Glycation End Products (AGEs)-Dependent Redox-sensitive Signaling(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
• PE-003 Increased Expression of Matrix Metalloproteinase-9 and Apoptosis Induced by Advanced Glycation Endproducts in Type 2 Diabetes : Implications for Plaque Instability(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70t
• OJ-262 A Role of Reactive Oxygen Species in Coronary Spasm(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-164 Essential Role of Rapid Geranylgeranylation from Unprocessed RhoA in RhoA Activation and Increase in Unprocessed RhoA in Atherosclerosis(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Monocyte Adhesion to Endothelial Cells Activates p47phox/NF-kB via Renin-Angiotensin System(RAS), Resulting in Gene Induction of MCP-1, ICAM-1 and Tissue Factor (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulatio
• Activation of CCR2 by MCP-1 Accelerates TF Expression via Ca2+ Influx in Monocyte Adhesion to Nitric Oxide (NO)-Impaired Endothelial Cells(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Blockade of Renin-angiotensin System (RAS) Inhibits Oxidized LDL-induced Superoxide Generation by Suppressing NADPH Oxidase Component Nox-4, p47 phox and Rac(Atherosclerosis, Basic 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
• Membrane type 1 Metalloproteinase (MT1-MMP) is Involved in the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• -1128-PHOSPHATIDYLINOSITOL TURNOVER-INDUCED PROTEIN PHOSPHORYLATION IN HUMAN MONOCYTE-DERIVED MACROPHAGES STIMULATED BY NATIVE AND CHEMICALLY MODIFIED LDL : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0358-MECHANISM OF THE UPTAKE OF ASIALO LDL BY MACROPHAGES
• METABOLISM OF ASIALO-LDL IN HUMAN MONOCYTE-DERIVED MACROPHAGES : Arteriosclerosis : 53 Annual Scientific Meeting, Japanese Circulation Society
• PHOSPHATIDYLINOSITOL TURNOVER IN HUMAN MONOCYTE-DERIVED MACROPHAGES STIMULATED BY NATIVE AND CHEMICALLY MODIFIED LDL : Arteriosclerosis : 53 Annual Scientific Meeting, Japanese Circulation Society
• Difference in Early Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Women
• PJ-250 Difference in Short-term Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Japanese Women(Echo/Doppler-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-170 Assessment of Microvascular Dysfunction by Myocardial Blood Velocity in Patients with Hyperlipoproteinemia(Echo / Doppler-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-275 Improvement of Microvascural Dysfunction by Cholesterol-lowering Therapy in Patients with Hypercholesterolemia is Different between Forearm and Coronary Arterial Beds(Echo/Doppler-5 (I) OJ46,Oral Presentation (Japanese),The 70th Anniversary Annual
• OJ-171 Myocardial Flow Velocity at Rest Predicts Improvement of Systolic Function in Patients with Dilated Cardiomyopathy(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
• A Positive Correlation of the Grade of Endothelial Dysfunction between Forearm and Coronary Arterial Beds in Patients with Hyperlipidemia (Peripheral Circulation/Vascular Disease 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
• Myocardial Flow Velocity at Rest Predicts Functional Prognosis of Dilated Cardiomyopathy(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-188 The Detection of Microheterogeneity in Myocardial Perfusion by Myocardial Contrast Echocardiography(Echo/Doppler 8 (I) : PE32)(Poster Session (English))
• Detection of microvascular dysfunction by intravenous contrast echocardiography in patients with dilated cardiomyopathy
• Continuous Observation of Superoxide Generation in an In-Situ Ischemia-Reperfusion Rat Lung Model
• P433 CORONARY MICROVASCULAR FUNCTION AND THALLIUM-201 SPECT FINDINGS IN PATIENTS WITH EXERCISE INDUCED ISCHEMIC ST CHANGES BUT NORMAL CORONARY ARTERIES
• 0016 Predictive value of sequential quantitative exercise thallium-201 scintigraphies for restenosis in asymptomatic patients after successful percutaneous transluminal coronary angioplasty
• -P330- THE TIME COURSE OF SUPEROXIDE GENERATION IN IN SITU ISCHEMIA-REPERFUSED RAT LUNG(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• The production of superoxide in short time ischemia-reperfused in vivo rat heart
• Microvascular Thrombosis in the Hepatic Vein of a Patient with Paroxysmal Nocturnal Hemoglobinuria
• Role of Ca^ Influx in Tissue Factor Expression in Monocyte Adhesion to Endothelial Cells
• Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure
• PE-322 SPECT/CTCA Fusion Image is Useful for the Diagnosis of Coronary Artery Stenosis with Calcification(PE054,CT/MRI (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-027 Adaptive Servo Ventilation Improves Cardiac Function in Heart Failure Patients with Cheyne-Stokes Respiration(OE05,Obesity/SAS (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Cardiac Systolic and Diastolic Dysfunction in the Hypertensive and Insulin-Dependent Diabetic Heart in Rats
• Atherosclerotic plaque instability and the structural differenceof myocyte in autopsy case of diabetes mellitus
• Transient Improvement of Left Ventricular Function After Peripheral Blood Stem Cell Transplantation in a Patient With Myelodysplastic Syndrome and Dilated Cardiomyopathy
• PJ-248 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• Successful Treatment with Cyclosporine and High-Dose Gamma Immunoglobulin for Persistent Parvovirus B19 Infection in a Patient with Refractory Autoimmune Hemolytic Anemia
• Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas
• Successful treatment of two patients with primary cardiac malignant lymphoma
• Increased high frequency components of QRS complex detected by wavelet analysis predicts vulnerability to ventricular tachycardia in hypertensive rats
• Comprehensive Analyses of Arrhythmogenic Substrates and Vulnerability to Ventricular Tachycardia in Left Ventricular Hypertrophy in Salt-Sensitive Hypertensive Rats
• Left Ventricular Dysfunction and Remodeling in Streptozotocin-Induced Diabetic Rats
• Daily Exercise of Non-Ischemic Short Duration Ameliorates Heart Failure due to Coronary Stenosis in Rats(Exercise Test/Cardiac Rehabilitation 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• A Possible Mechanism of Worsening Heart Failure by High Cholesterol Diet without Progressing Epicardial Coronary Artery Stenosis Severity in Rats(Coronary Circulation, Basic/Clinical 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation
• Altered Effects of Angiotensin II Type 1 and Type 2 Receptor Blockers on Cardiac Norepinephrine Release and Inotropic Responses During Cardiac Sympathetic Nerve Stimulation in Aorto-Caval Shunt Rats
• PJ-549 The Novel Substrate Which Derives From Cultured Fibroblasts Improves Diastolic Dysfunction and Attenuates Infarction via PKC and Mitochondrial KATP Pathway(Myocardial Ischemia-Reperfusion, Basic and Clinical 4 (M) : PJ92)(Poster Session (Japanese))
• FRS-054 Continuous Decrease of Parasympathetic and Sympathetic Nervous Activities before Increased Sympathetic Nervous Activities Is Prerequisite to The Induction of Coronaryspasm(Oxidative Stress, Autonomic Function and Peripheral Vascular Diseases (H) :
• Vasoconstrictive Response in the Non-Exercising Forearm Vascular Beds during Leg Exercise in Patients with Chronic Heart Failure
• Responder and Hypo-Responder to the Treatment with Carvedilol in Rats with Ischemic Heart Failure
• High Cholesterol Diet Is a Risk Factor for Heart Failure through Coronary Microvascular Endothelial Nitric Oxide Dysfunction and Inflammation
• Endothelin A Antagonist Prevents the Development of Microvascular Spasm Induced by Repeated Endothelial Injury of Epicardial Coronary Artery
• The Mechanistic Insight of Amelioration of Chronic Heart Failure Due to Coronary Stenosis by Angiotensin Inhibition in Rats
• Embolic Attack in Patients With Atrial Fibrillation and Atrial Thrombus Depends on the Character of the Thrombus
• Different Contribution of Apoptosis to the Antiproliferative Effects of L-Arginine, Enalapril and Losartan on Neointimal Growth Inhibition After Balloon Arterial Injury
• Situation of sudden cardiac death, and electrocardiographic findings in life time
• Antioxidants prevent coronary microvascular dysfunction induced by repeated epicardial coronary artery endothelial denudation in pigs
• IS116 Increased Plasminogen Activator Inhibitor-1 and Lipoprotein(a) in Coronary Atherectomy Specimens in Acute Coronary Syndoromes : Implication of Impaired Fibrinolysis
• MCP-1 receptor blocker attenuates myocardial inflammation, ventricular dysfunction and remodeling in rats with coronary stenosis fed with high cholesterol diet
• Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
• PJ-009 Endothelin Type A Receptor Antagonist Has a Protective Effect on Coronary Microvascular Spasm Induced by Repeated Epicardial Endothelial Injury(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annual S
• OJ-420 Protective effect of chronic endothelin type A receptor antagonist on coronary microvascular spasm induced by repeated epicardial endothelial injury.(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese))
• FRS-068 Chronic endothelin type A receptor antagonist has a protective effect on coronary spasm induced by repeated epicardial endothelial injury.(Atherosclerosis (IHD) : FRS8)(Featured Research Session (English))
• PJ-460 Metabolic Regulation of Coronary Vascular Tone through Redox Modulation(Coronary circulation, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Arterial carboxyhemoglobin, a product of heme oxygenase-1 activation, elevates in the patients with congestive heart failure
• Multiple endothelial injury in epicardial coronary artery induces downstream microvascular spasm through oxygen free radical and endothelin-1
• Antioxidant therapy prevents coronary artery spasm in pig
• Blockade of Endothelin-1 Prevents Coronary Spasm Induced by repeated Epicardial Endothelial Injury in a Pig Model (Endothelium/NO 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Chronic Endothelin Type A Antagonist is Effective to Prevent Coronary Microvascular Spasm Induced by Repeated Endothelial Injury(Coronary Circulation, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of β-Blockers on Coronary Spasm Induced by Repeated Epicardial Coronary Artery Endothelial Denudation in Pigs
• Ascorbyl free radical and thiobarbiturate reactive substance in Patients with Non-Ischemic and Ischemic Heart Disease
• Ascorbyl free radical as an index of overall oxidative stress in patients with chronic heart failure
• Prediction of Embolism in Atrial Fibrillation : Classification of Left Atrial Thrombi by Transesophageal Echocardiography
• 0688 DEVELOPMENT OF PIG CORONARY MICROVASCULAR SPASM MODEL AND RELATION OF NITRIC OXIDE
• ALTERATION OF RESPONSES TO VASOACTIVE AGENTS IN THE PROCESS OF REPEATED ENDOTHELIAL. INJURY AND REGENERATION IN A PIG CORONARY ARTERY
• The Association of Circadian Variation in Patients with Paroxysmal Atrial Fibrillation and Insulin Resistance (Diabetes/Obesity 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Anti-inflammatory and cardioprotective effects of daily exercise training in rats with chronic myocardial ischemia and fed with high cholesterol diet
• Comparison of Long-Term Clinical Outcomes of CHOP Chemotherapy between Japanese Patients with Nodal Peripheral T-Cell Lymphomas and Those with Diffuse Large B-Cell Lymphoma in the Study Group of the Tohoku Hematology Forum
• IS176 Anti-remodeling Effect of the Combination of the ACE Inhibitor and AT1 Receptor Antagonist in a Rat Model of Coronary Stenosis
• Complement and Polymorphonuclear Leukocyte Activation Each Play a Role in Determining Myocardial Ischemia-Reperfusion Injury
• Evidence for coronary eNOS activation by carvedilol comparable to ACE inhibitor and ARB in chronic ischemic myocardium in rats
• T-cell prolymphocytic leukemia in Japan : is it a variant?

もっと見る 閉じる

スポンサーリンク