Left Ventricular Dysfunction and Remodeling in Streptozotocin-Induced Diabetic Rats

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• Background It is not fully clarified how diabetes mellitus (DM)-induced cardiac dysfunction is associated with histopathological changes of the heart in a long lasting period of DM. Methods and Results Eighteen weeks after a streptozotocin injection was given to Wistar-Kyoto rats (D rats), echocardiography and hemodynamic studies including the dobutamine infusion test were performed. After perfusion fixation, immunofluorescent staining and histopathology of the heart were analyzed, and analysis with electron microscopy was also conducted. Systolic blood pressure in the conscious state and left ventricular (LV) ejection fraction by 2-dimensional echocardiography were reduced in D rats. LV mechanical responses to dobutamine assessed by maximal LV pressure derivative (+LVdP/dt) also decreased with higher dobutamine doses in D rats. Although LV and right ventricular (RV) wall thickness were smaller in D rats, there were increased RV volumes, indicating LV and RV dilatational remodeling in D rats. The cardiomyocyte transverse diameter and actin staining in cardiomyocytes in both the LV and RV were significantly reduced, and capillary tortuosity and type IV collagen were increased, indicating microangiopathy in D rats. Conclusions Advanced insulin-dependent DM incurred not only RV remodeling but also overt resting LV systolic dysfunction and decreased LV responsiveness to β adrenergic stimulation with dilatational remodeling, accompanied by pathological changes of capillaries and cardiomyocytes including actin filaments.

• 社団法人日本循環器学会の論文
• 2006-02-20

著者

• 矢尾板 裕幸

  福島県立医科大学第一内科

• Yaoita Hiroyuki

  First Department of Internal Medicine, Fukushima Medical University

• Murai Kazunori

  岩手医科大学 病理学

• Kawaguchi Michiko

  First Department of Internal Medicine, Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  First Depertment of Internal Medicine, Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical College

• Murai Kazunori

  Department Of Internal Medicine Hematology/oncology Iwate Medical University School Of Medicine

• Miyake Katsuya

  Second Department Of Anatomy Fukushima Medical University

• Yaoita Hiroyuki

  Department Of Cardiology And Hematology Fukushima Medical University

• Yaoita Hiroyuki

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  Department Of Internal Medicine Hematology/oncology Iwate Medical University School Of Medicine

• Maehara Kazuhira

  First Department Of Internal Medicine Fukushima Medical University

• MAEHARA Kazuhiro

  The First Department of Internal Medicine Tohoku University School of Medicine

• Nemoto Osamu

  First Department of Internal Medicine, Fukushima Medical University

• Nemoto Osamu

  First Department Of Internal Medicine Fukushima Medical University

• Kawaguchi Michiko

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kaztuhira

  First Department Of Internal Medicine Fukushima Medical University

• Maehara Kazuhira

  福島県立医科大学 第1内科

• Maehara Kazuhira

  Internal Medicine Shirakawa Kousei Hospital

• Murai Kazunori

  Department Of Hematology/oncology Internal Medicine Iwate Medical University

• Maehara Kazuhira

  First Department Of Internal Medicine

• Yaoita Hiroyuki

  First Department Of Internal Medicine Fukushima Medical College

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