Sequential Changes of Hepatocyte Growth Factor in the Serum and Enhanced c-Met Expression in the Myocardium in Acute Myocardial Infarction
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概要
- 論文の詳細を見る
A 68-year-old male with acute myocardial infarction(AMI)was admitted to the hospital with chest pain that had started 1 day earlier. The serum levels(ng/ml)of hepatocyte growth factor(HGF)were 1.06, 1.22, 1.05, 0.72 and 0.64 on days 2, 3, 4, 5 and 6 postinfarction, respectively. He died suddenly due to cardiopulmonary arrest on day 6. At autopsy, approximately 400ml of bloody pericardial fluid, caused by rupture of the left ventricle, was detected and the c-Met expression in the myocardium was immunohistochemically found to be most intense in the border zone of the infarcted and non-infarcted region. Although there was no c-Met expression in the infarcted myocardium, it was increased in the myocardial cells surrounding the blood vessels. This is the first report to show sequential changes of HGF in the serum, as well as c-Met expression in the myocardium, in a patient with AMI.
- 社団法人日本循環器学会の論文
- 1999-10-20
著者
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SATO Hirohiko
Department of Chemistry,Graduate School of Science and Engineering,Tokyo Institute of Technology
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TAKEUCHI Tamotsu
Department of Pathology, Kochi Medical School
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OHTSUKI Yuji
Department of Tumor Pathology, Kochi Medical School
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SATO Tetsuya
Department of Pediatrics, Kochi Medical School, Kochi University
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Sato Hirohiko
The Department Of Cardiovascular Medicine Matsuyama City Hospital
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Sato Tetsuya
Department Of Cardiology Okayama Red Cross General Hospital
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Fujieda Hiroyuki
Department of Cardiovascular Medicine
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Sato Tetsuya
Department Of Cardiology Okayama Redcross Hospital
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Murao Satoshi
Department of Cardiovascular Medicine, Matsuyama Shimin Hospital
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Sakamoto Taisuke
The Department Of Cardiovascular Medicine Matsuyama City Hospital
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Murao Satoshi
Department Of Bone And Joint Surgery Seirei Hamamatsu General Hospital
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Ohtsuki Yuji
Department Of Pathology Kochi Medical School
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Ohtsuki Yuji
Department Of Pathology Kochi Medical School Nankoku
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Murao Satoshi
The Department Of Cardiovascular Medicine Matsuyama City Hospital
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Fujieda Hiroyuki
The Department Of Cardiovascular Medicine Matsuyama City Hospital
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Sato Hirohiko
Department Of Chemistry Faculty Of Science Kyoto University
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Takeuchi Tamotsu
Department Of Pathology Kochi Medical School Nankoku
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Takeuchi Tamotsu
Department Of Immunology National Institute Of Neuroscience National Center Of Neurology And Psychia
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Sato Hirohiko
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Sato Tetsuya
Department Of Agricultural Chemistry Obihiro University Of Agriculture And Veterinary Medicine
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Sakamoto Taisuke
Department Of Cardiology Okayama Red Cross General Hospital
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