Adenosine-Induced Coronary Flow Reserve in Watanabe Heritable Hyperlipidemic Rabbits
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概要
- 論文の詳細を見る
The Watanabe heritable hyperlipidemic(WHHL) rabbit develops coronary atherosclerosis and hypercholesterolemia because of agenetic deficiency of low-density lipoprotein receptors and is therefore a good animal model for studying the relationships of coronary atherosclerosis, hypercholesterolemia and coronary flow reserve. The aim of the present study was to assess myocardial perfusion at baseline and during adenosine infusion (0.2mg・kg^<-1>・min^<-1>) in 8 WHHL rabbits (13.8±0.5 months) with ^<13>N-ammonia, small-animal positron emission tomography(PET) and colored microspheres. Results were compared with those from 6 age-matched Japanese white rabbits. Plaque distribution was also examined in the extramural coronary arteries. All 8 WHHL rabbits had coronary plaques, with 6 showing multiple plaques. Mean global myocardial blood flow (ml・min^<-1>・g^<-1>) did not differ significantly between control and WHHL groups both at baseline (3.67±0.72 vs 4.26±1.12ml・min^<-1>・g^<-1>, p=NS) and with adenosine (7.92±2.00 vs 9.27±2.91 ml・min^<-1>・g^<-1>, p=NS), nor did coronary flow reserve (2.16±0.37 vs 2.18±0.41, p=NS). None showed evidence of regional perfusion abnormalities by visual and semiquantitative analyses of PET images. It was concluded that WHHL rabbits preserve adenosine-induced coronary flow reserve despite coronary atherosclerosis and hypercholesterolemia, suggesting that a compensatory mechanism develops in this animal model.
- 社団法人日本循環器学会の論文
- 2000-11-20
著者
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Takano H
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Shiomi Masashi
Institute For Experimental Animals Kobe University School Of Medicine
-
Ueda Makiko
Department Of Pathology Osaka City University Graduate School Of Medicine
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Komatsu Ryushi
Department Of Cardiology Osaka City General Hospital
-
Komatsu Ryushi
Department Of Pathology Osaka City University Medical School
-
Takami Akira
Third Department Of Internal Medicine Chiba University School Of Medicine
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Yoshida Katsuya
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Yoshida Katsuya
Third Department Of Internal Medicine Chiba University School Of Medicine
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MASUDA Yoshiaki
Third Department of Internal Medicine, Chiba University School of Medicine
-
Ueda Makiko
Department Of Pathology Graduate School Of Medicine Osaka City University
-
Tanada Shuji
Department Of Medical Physics National Institute Of Radiological Sciences
-
Tanada Shuji
National Institute Of Radiological Sciences
-
Shiomi Masashi
Institute For Experimental Animals Kobe University Graduate School Of Medicine
-
Masuda Yoshiaki
The Japanese Society Of Ct Screening
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SUZUKI Kazutoshi
Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences
-
Tadokoro Hiroyuki
Division Of Cardiovascular Surgery Department Of Surgery St. Marianna University School Of Medicine
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TANADA Shuji
Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences
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Shimada Kazuhiro
Third Department of Internal Medicine, Chiba University School of Medicine
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Kitsukawa Shinobu
Third Department of Internal Medicine, Chiba University School of Medicine
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Tanada Shuji
Division Of Advanced Technology For Medical Imaging National Institute Of Radiological Sciences
-
Suzuki Kazutoshi
Division Of Advanced Technology For Medical Imaging National Institute Of Radiological Sciences
-
Kitsukawa Shinobu
Third Department Of Internal Medicine Chiba University School Of Medicine
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Tanada Shuji
Research Center Of Charged Particle Therapy National Institute Of Radiological Sciences
-
Masuda Yoshiaki
Third Department Of Internal Medicine Chiba University School Of Medicine
-
Shimada Kazuhiro
Third Department Of Internal Medicine Chiba University School Of Medicine
-
Kitaura Yasushi
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
-
Masuda Yoshiaki
Third Department Of Internal Medicine Chiba University
-
Masuda Yoshiaki
The Third Dept. Of Internal Medicine Chiba University School Of Medicine
-
Tadokoro Hiroyuki
Division Of Advanced Technology For Medical Imaging National Institute Of Radiological Sciences
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