Spectral Characteristics of Human Atrial Fibrillation Waves of the Right Atrial Free Wall With Respect to the Duration of Atrial Fibrillation and Effect of Class I Antiarrhythmic Drugs
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概要
- 論文の詳細を見る
The aim of this study was to use fast Fourier transform analysis to clarify the characteristics of human atrial fibrillation(AF)waves with respect to the duration of AF and the effect of class I antiarrhythmic drugs. Twentytwo patients(10 paroxysmal AF, 12 persistent AF)without organic heart disease were studied by conventional electrophysiological methods. Electrograms were recorded from the right atrial free wall during AF and spectral analysis was performed for 35s(16 consecutive 4096-ms epochs with 50% overlap)and the fibrillation cycle length(FCL)was calculated from the peak frequency. Mean FCL and SD were determined from 16-epoch data, and the temporal variability of FCL was defined as the SD of FCL. Paroxysmal AF had a longer mean FCL than persistent AF(178±26ms vs 139±16ms, p<0.001)and AF duration had a significant inverse correlation with mean FCL(r=-0.79, p<0.001). The temporal variability of FCL was significantly greater in paroxysmal AF than in persistent AF(p<0.05)and there was a significant positive correlation between the mean FCL and the temporal variability of FCL(r=0.66, p<0.001). In 8 of 18 patients given a class I antiarrhythmic drug(cibenzoline or procainamide), AF was terminated and in those patients the mean FCLs before administration of class I drugs were significantly greater than in patients without AF termination. With respect to mean FCL before drug administration, conversion occurred in 100% of patients with FCL ≥168ms and in 17% of those with FCL <168ms. A longer duration of AF shortens the mean FCL, which is consistent with atrial electrical remodeling. Class I drugs prolong the mean FCL above a critical level and will terminate AF, which can be estimated from the mean FCL before drug administration.
- 社団法人日本循環器学会の論文
- 2001-11-20
著者
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Fujiki Akira
Second Department Of Internal Medicine University Of Toyama
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Fujiki Akira
The Second Department Of Internal Medicine
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MIZUMAKI Koichi
The Second Department of Inetranal Medicine, Toyama Medical and Pharmaceutical University
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Sakurai Kenji
The Second Department Of Internal Medicine University Of Toyama
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Sakabe Masao
The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Nagasawa Hidehiko
The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama
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Miwa Kunihisa
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Nishida Kunihiro
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Nagasawa Hidehiko
The Second Department Of Internal Medicine Faculty Of Medicine University Of Toyama
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Inoue Hiroshi
The Second Department Of Internal Medicine University Of Tokyo
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Sakurai Kenji
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine
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