Acute-Phase Proteins and Chlamydia pneumoniae Infection : Which One is More Important in Acute Coronary Syndrome?
スポンサーリンク
概要
- 論文の詳細を見る
Elevated levels of acute-phase proteins, a systemic marker for inflammation, predict coronary events; Chlamydia pneumoniae(C.pneumoniae)infection is associated with coronary atherosclerosis. The present study investigated whether inflammation or infection is involved in the pathogenesis of acute coronary syndrome(ACS)and which one has the more important role. The study group comprised 49 patients with angiographically diagnosed ACS, 48 cases of chronic coronary heart disease(CCHD), and 44 subjects with a normal coronary profile. The levels of serum C-reactive protein(CRP), fibrinogen and anti-C.pneumoniae IgG antibody were measured. The IgG antibody against C.pneumoniae was higher in the ACS and CCHD groups compared with the control group after adjusting for age and gender. The levels of CRP and fibrinogen were significantly increased in patients with ACS compared with controls and CCHD patients. Multiple stepwise logistic regression analysis revealed that C.pneumoniae IgG antibody is an independent risk factor for both ACS and CCHD(odds ratio 2.3 and 2.1, respectively), but the CRP level is a risk factor only for ACS(odds ratio 6.9). The inflammatory response, as indicated by acute-phase proteins, especially CRP, rather than C.pneumoniae infection, may contribute more to the clinical course of ACS.
- 社団法人日本循環器学会の論文
- 2001-09-20
著者
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Yamashita Kazuhito
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Tasaki Hiromi
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Tasaki Hiromi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health Japan Sc
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Yashiro Akira
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Yashiro Akira
Second Department Of Internal Medicine University Of Occupational And Environ-mental Health School O
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Nakashima Yasuhide
Second Depadment Of Internal Medicine University Of Occupational And Environmental Health
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Yamamoto Kiyoko
The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ
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Taniguchi Hatsumi
Department Of Microbiology School Of Medicine University Hospital University Of Occupational And Env
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Taniguchi Hatsumi
Department Of Microbiology University Of Occupational And Environmental Health School Of Medicine
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Song Hongmei
Second Department of Internal Medicine, University of Occupational and Environmental Health, School
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Yamashita Kazuhito
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Song Hongmei
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of Medicine
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