病原真菌の抗体成分と免疫学的活性 : 第3報抗Candida albicansおよび抗Aspergillus fumigatusウサギ血清の抗体諸成分の受け身皮膚アナフィラキシー活性

概要

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In an attempt to investigate the responsibility of antibodies of anti-fungus sera for hypersensitivity in mycotic infections, were performed experiments by means of passive cutaneous anaphylaxis technique. As antibodies were used the IgG, IgA and IgM components from the anti-Candida albicans C-a-13 strain and anti-Aspergillus fumigatus As-f-6 strain rabbit sera described in the previous paper^* in various contents and as antigens the cell-free extracts in 10 μg N obtained from the cultures of the respective strains employed in immunization mixed with Evans blue. Test animals were guinea pigs. The results obtained were as follows. In the both homologous antigen-antibody systems, the IgG-1 antibody proved the most active in PCA reaction, whereas the IgA and IgM antibodies were not so active as to all their fractions, positive in 1-10 μg N. Thus it might be concluded that IgG antibody is mainly responsible for hypersensitivity in terms of PCA reaction in pathogenic fungi and IgA and IgM antibodies do not play an important role in this property, as far as the test strains of C. albicans and A. fumigatus are concerned at least. ^*It is press in this journal.
日本アレルギー学会の論文
1968-05-30