病原真菌の抗体成分と免疫学的活性 : 第1報.抗Candida albicansおよび抗Aspergillus fumigatusウサギ血清の抗体成分の分離精製

概要

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In an attempt to clarify antibodies produced by pathogenic fungi and their immunologic activities, several experiments were maid. This paper deals with fractionation and purification procedures of the immunoglobulins from anti-Candida albicans and anti-Aspergillus fumigatus rabbit sera and their electrophoretic patterns. In the DEAE-cellulose column chromatogram of the crude gammaglobulins obtained from the anti-C. albicans and anti-A. fumigatus sera by ammonium sulfate fractionation were seen seven peaks, IgG-1, IgG-2, IgA-1, IgA-2, IgA-3, IgM-1 and IgM-2 fractions and five peaks, IgG-1, IgA-1, IgA-3, IgM-1 and IgM-2 fractions, respectively, which were temporarily designated for convenience. The main component was the IgG-1 fraction appropriate to so-called IgG antibody, a main component of any immunoglobulins, either, and the IgA-3 and IgM-1 fractions were also recognized to exist in considerable amount, especially, in case of Aspergillus globulin. Thus it is to be noted that the immunoglobulins from anti-fungus sera are characteristic in quality and quantity, compared with those of any other orgin.
日本アレルギー学会の論文
1968-05-30