病原真菌の抗体成分と免疫学的活性 : 第2報.抗Candida albicansおよび抗Aspergillus fumigatusウサギ血清の抗体諸成分の感染防禦効果

概要

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In view of the present status that preventive and curative effects of anti-fungus sera and their antibody components have not been clarified yet, the authors attempted to investigate such effects of the IgG-1, IgA-3, and IgM-1 components from the anti-Candida albicans and anti-Aspergillus fumigatus rabbit sera described in the preceding paper^* against the experimental infections of mice with organisms of their respective strains. One mg of the antibody components was intraperitoneally administeted to each mouse of DD strain each once before and after the intravenous challenge with 1×10^6 yeast cells of C. albicance C-a-13 strain and also with the same number of conidia of A. fumigatus As-f-6 strain. In the both infections, all the treated groups of mice were significantly smaller in mortality than the non-treated control ones;the IgG-1 fraction exhibited the most conspicuous preventive effect, the IgM-1 came next and the IgA-3 showed only a slight degree of activity. ^*It is in press in this journal.
日本アレルギー学会の論文
1968-05-30