8. N-p-chlorbenzhydryl-n-methyl homopiparazine dihydrochloride : ホモクロミンの抗アナフィラキシー作用機序(第2回プラズマキニン研究会)

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The administration of 0.5 mg of N-p-chlorbenzhdryl-n-methylhomopiparazine dihydrochoride (homoclomin) suppressed completely anaphylactic death in guinea pigs. It had no effect on an increase of plasma plasmin activity in anaphylactic shock in guinea pigs. The administrain of homoclomin had no effect on the defibrination syndrome in anaphylactic shock in rabbits. A marked hemoconcentration was demonstrated in anaphylactic rabbits, showing an increase of red cell counts, hemoglobin content and hematocrit value. A marked decrease of total plasma protein and albumin was also demonstrated. A marked decrease of circulating blood volume and plasma volume was demonstrated in anaphylactic rabbits, by ^51Cr tagged red cell method. No changes of circulating red cell volume were seen. The Evans blue space increased markedly in anaphylatic shock in rabbits. The calculated albumin volume which escaped from crsulating blood was more than 50% of total blood volume. The administraion of homoclomin inhibited the above mentioned hemoconcentration, a decease of total blood volume, an increase of evans blue space and the exudation of plasma albumin in anaphylactic shodk in rabbits. Serum of anaphylactic animals showed a permeability promoting action. Homoclomin inhibited the permeability promoting action of anaphylactic serum and bradykinin. These results indicate that the rapid decease of circulating blood volume due to increased vascular permeability plays a significant role in the mechanism of anaphylactic shock and the suppression of the increased vascular permeability is the important factor in the mechanism of anti-anaphylatic effect of homoclomin.
日本アレルギー学会の論文
1968-04-30

8. N-p-chlorbenzhydryl-n-methyl homopiparazine dihydrochloride : ホモクロミンの抗アナフィラキシー作用機序(第2回プラズマキニン研究会)

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