寒冷蕁麻疹の Chemical Mediator

概要

論文の詳細を見る
The chemical mediator of a cold urticaria patient was examined. This wheal was not prevented by diphenhydramine (an antihistamine) or aprotinin (Trasylol, an antikallikrein agent), and decreased after the recurrent cold stimuli or the injection of sinomenine (a mast cell degranulating agent). Histamine was not demonstrated in the skin of the patient by the dermal perfusion technique when ice was applied. The dermal perfusion technique consists of a delivery and a collecting needle inserted superficially 0.5 cm apart into the dorsal skin of the forearm, with sterile isotonic saline entering the skin at the delivery site, perfusing the dermal-subcutaneous tissue, and via the collecting needle. The dermal perfusate was examined by a rabbit vein bioassay. Kinin activity was present in the dermal perfusate. 5-HT or histamine was not found in the perfusate by the thin layer chromatography technique. The increasing of plasminogen activator activity and plasmin activity by application of ice was not found. In this case, it may be possible to explain the localized and systemic reactions of cold urticaria by kinin effect since kinins were found in the persusion fluid of the wheal induced by cold. The kinin forming enzyme activity of the mast cells may increase by application of cold, and these may split plasma proteins to produce kinins.
日本アレルギー学会の論文
1969-08-30