3. 炎症局所における Histamine および Bradykinin の役割

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In order to confirm a possible role of histamine and bradykinin in the process of inflammation the granuloma pouch technique was performed on the back of mice. The specimens were taken from induced granulomas at several intervals. First, volumes and ammonia concentrations of the exudate in each of the pouches were estimated, and then weights and hydroxyproline contents of the granuloma were determined. 1) In the control group, measurable amounts of specimens with the above described methods were formed on the 3rd day (the initial phase), increased up to the 7th day (the maximum phase), and decreased on the 10th day, but hydroxyproline contents of the granuloma continued to elevate (the reparative phase). 2) Repeated intra-pouch applications of dexamethasone (50γ) elicited a marked suppression of the formation of both exudate and granuloma throughout the observed period. 3) Repeated intra-pouch injections of histamine (25γ) increased the volume and ammonia concentration of the exudate and the weight of granuloma, but hydroxyproline contents of the granuloma remained at a low level. These pattern became markedly as the time elapsed (enhancement of effects and prolongation of the maximum phase). Influences of bradykinin (3γ) were similar to those of histamine qualitatively, but they were more intense at the initial phase (enhancement of effects at the initial phase). 4) With a combined use of dexamethasone with histamine, actions of the latter remarkably antagonized, while effects of bradykinin were hardly influenced by corticosteroid at the initial phase.
日本アレルギー学会の論文
1969-06-30

3. 炎症局所における Histamine および Bradykinin の役割

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