7.分離マスト細胞におけるHistamine遊離物質と消炎剤の拮抗関係について(第4回プラスマキニン研究会)

概要

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1) The mast cells isolated from the peritoneal fluid of rats are easily degranulated following the incubation with either α-chymotrypsin (10-300γ/ml), sinomenine (3-100γ/ml), dextran (100-1, 500γ/ml)or compound 48/80 (0.1-1 γ/ml). The activity is approximately equal to α-chymotrypsin in a concentration of 300γ/ml, sinomenine in that of 100γ/ml and compound 48/80 in that of 0.5γ/ml and some what weaker in 1,500γ/ml of dextran. 2) Preincubation of the mast cells with either diphenhydramine (10-1,000γ/ml), cyproheptadine (1-100γ/ml), homochlorcyclizine(1-100γ/ml) or dexamethasone (0.1-10γ/ml) antagonizes the effect by the histamine liberators. The activity of cyproheptadine, homochlorcyclizine and desamethasone is approximately the same in potency, while that of diphenhydramine is somewhat weaker than that of the others.
日本アレルギー学会の論文
1970-08-30