5.BradykininにおけるHistamine遊離物質としての性格の有無に関する検討(第2回プラズマキニン研究会)

概要

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1. Intradermal injection of bradykinin in a dose of 0.01 γ to mice caused a marked increase of capillary permeability, but this action of the compound was not influenced by the pretreatment of either dixtran(3, 600 mg/kg, i.p.)or sinomenine(2, 000 mg/kg, in successive 5 days, s.c.), both of which were potent histamine liberators. 2. Local edema induced by subcutaneous administration of 1 γ of bradykinin to mice was not affected by the pretreatment of the above described histamine liberators. 3. Repeated intracutaneous applications of 1 γ of bradykinin did not alter the reactivity of the local skin to the substance. 4. Local edema produced by subcutaneous injection of either dextran or formalin both of which were histamine liberators was not influenced by the pretreatment of bradykinin. 5. Intravenous administration of large amounts of bradykinin (30 mg/kg) caused a considerable degranulation of the mast cells at the abdominal skin of mice an hour after the application, but this histological change almost returned to normal within 3 hours. When the dosis was reduced to 15 mg/kg, no significant changes were observed. 6. Thus, there would be no possibility that bradykinin plays a role of histamine liberator, except for the case of early stage when large amounts of the compound are applied.
日本アレルギー学会の論文
1968-04-30