Hybrid Scaffolds for Tissue Engineering

概要

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Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. The most commonly used porous scaffolds can be constructed from two kinds of biodegradable polymers : synthetic biodegradable polymer and natural polymer. Because synthetic polymers and naturally derived polymers have their respective advantages and drawbacks, they have been hybridized to combine their advantages. We developed two kinds of hybrid biodegradable porous scaffolds by hybridizing PLGA with naturally derived collagen. One is their hybrid sponge prepared by introducing collagen microsponges in the pores of PLGA sponge. The other one is their hybrid mesh prepared by forming collagen microsponges in the interstices of PLGA mesh. Observation by scanning electron microscopy showed that microsponges of collagen with interconnected pore structures were formed in the pores of PLGA sponge or in the interstices of PLGA mesh. The polymer sponge, or mesh serving as a skeleton, reinforced the hybrid sponge, or mesh and resulted in easy handling, while the collagen microsponges provided the hybrids with a microporous structure and hydrophilicity, and therefore, easy cell seeding. These hybrid scaffolds could be useful for tissue engineering.
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