Formation of 2,5-Diamino-4-Hydroxy-6-(2'-Deoxyribosyl)-Formamidopyrimidine from 2'-deoxyguanosine in Aqueous Solution Irradiated with ^<60>Co Gamma-Rays
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概要
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2'-Deoxyguanosine in aqueous solution (5 x 10^<-4>mol/dm^3) was irradiated with ^<60>Co gamma-rays under N_2O. Products were separated by gel chromatography (Cellulofine GC-15-m) and high performance liquid chromatography (Inertsil ODS-2). 2-Amino-4-hydroxy-5-formamido-6-(2'-deoxyribosyl)-aminopyrimidine was one of the main radiolytic products. The formation of 2, 5-diamino-4-hydroxy-6-(2'-deoxyri-bosyl)-formamidopyrimidine was detected, this compound being verified by measuring its ultraviolet absorption spectrum and analyzing its trimethylsilylated derivative by gas chromato-mass spectrometry. Its yield in terms of 2-amino-4-hydroxy-5-formamido-6-(2'-deoxyribosyl)-aminopyrimidine was 1:3. Reactions of ionizing-radiation-generated free radicals with DNA and its consituents have been investigated extensively. A large number of products from both the pyrimidine and purine bases have been identified1-3).
- 日本放射線影響学会の論文
著者
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YAMAMOTO Osamu
Department of Applied Chemistry, Kanagawa Institute of Technology
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Ali Mohsin
Department Of Biology Faculty Of Sciences Hiroshima University
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Yamamoto Osamu
Department Of Biology Faculty Of Sciences Hiroshima University
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Yamamoto Osamu
Department Of Applied Chemistry Kanagawa Institute Of Technology
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