SCID (Severe Combined Immunodeficiency) Mice as a New System to Investigate Metastasis of Human Tumors

スポンサーリンク

概要

• 論文の詳細を見る

• In severe combined immunodeficiency (scid) mice which are deficient in T and B cell functions, human yolk sac tumor (YST-2) grew rapidly to enormous sizes in all of the animals after both subcutaneous and intraperitoneal transplantation, while only half of the subcutaneous and none of the intraperitoneal transplants were accepted in usual athymic nude mice. Furthermore, transplanted tumors metastasized spontaneously to distant organs such as lung, liver, kidney, pancreas, and spleen in scid mice, while metastases were not found in athymic nude mice. Similar results were observed in scid mice and scid-nude (streaker) double mutant mice with human classic (typical) seminoma which has been neither transplantable nor metastatic in athymic nude mice. Thus, scid mice provide an invaluable experimental system to investigate the mechanism of metastasis which is the most important and life-threatening problem in cancer patients.

• 日本放射線影響学会の論文

著者

• 野村 大成

  大阪大学医学部癌研,放基

• Takahama Yousuke

  Biomedical Research Center Faculty Of Medicine Osaka University

• Takahama Yousuke

  大阪大学 放射線基礎医

• 野村 大成

  大阪大学医学部 放射線基礎医学講座

• HONGYO TADASHI

  Department of Radiation Biology, Faculty of Medicine, Osaka University

• INOHARA HIDENORI

  Department of Radiation Biology, Faculty of Medicine, Osaka University

• TAKATERA HIROSHI

  Department of Radiation Biology, Faculty of Medicine, Osaka University

• FUKUSHIMA HISAO

  Department of Radiation Biology, Faculty of Medicine, Osaka University

• ISHII YUTAKA

  Department of Radiation Biology, Faculty of Medicine, Osaka University

• HAMAOKA TOSHIYUKI

  Biomedical Research Center, Faculty of Medicine, Osaka University

• HAMAOKA Toshiyuki

  Department of Oncology (C6), Osaka University Graduate School of Medicine

• Hamaoka Toshiyuki

  Department Of Oncology (c6) Osaka University Graduate School Of Medicine

• Hamaoka Toshiyuki

  Biomedical Research Center Faculty Of Medicine Osaka University

• Hamaoka Toshiyuki

  Biomedical Research Center Osaka University Medical School

• 野村 大成

  大阪大学医学部

• Hongyo Tadashi

  Department Of Radiation Biology Osaka University Graduate School Of Medicine

• Hongyo T

  Osaka Univ. Osaka Jpn

• Inohara Hidenori

  Department Of Otolaryngology And Sensory Organ Surgery Osaka University Graduate School Of Medicine

• Inohara Hidenori

  Department Of Radiation Biology Faculty Of Medicine Osaka University: Department Of Otolaryngology F

• Hamaoka Toshiyuki

  Department Of Oncology Osaka University Graduate School Of Medicine

• Fukushima Hisao

  Department Of Pediatrics Faculty Of Medicine Osaka University

• Fukushima Hisao

  Department Of Radiation Biology Faculty Of Medicine Osaka University

• Takatera Hiroshi

  Department Of Radiation Biology Faculty Of Medicine Osaka University

• Ishii Yutaka

  Department Of Applied Physics Waseda University

• Ishii Yutaka

  Department Of Radiation Biology Faculty Of Medicine Osaka University

• Ishii Yutaka

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

関連論文

• 免疫賦活物(Pyran, P.acnes)のウレタン誘発肺腫瘍に対する非抑制効果 : カフェインとの比較 : 関西支部 : 第36回日本肺癌学会関西支部会
• 合成洗剤による妊娠不成立 : マウス初期胚への致死効果
• Diethylstilbestrol の非ホルモン発がん性について : 関西支部 : 第33回日本肺癌学会関西支部会
• 18. アミノピリンの催奇形性に対するバルビタールおよびフェノバルビタールの促進効果
• 5. アミノピリン及びその分子化合物の催奇形性
• 安全の哲学
• ダイオキシンのマウス生殖細胞への影響 : シンポジウム : II. ダイオキシンの生体影響
• 環境汚染の次世代への影響
• S2-7 ダイオキシンの遺伝学的影響の問題点
• S2-序 序論
• γ線照射装置による校正場の散乱線の評価
• マウスモデルにおける継世代的影響リスク
• 新人為起源有害物質の継世代的人体影響
• γ線照射装置の照射野の自動制御
• 160 食道拡張症マウス (101/b) に関する神経生理学的研究(第34回日本消化器外科学会総会)
• High Sensitivity of Fertilized Eggs to Radiation and Chemicals in Mice: Comparison with that of Germ Cells and Embryos at Organogenesis
• 定量的発がん性試験法
• ヒトSeminomaのscid-nu^二重変異マウスでの継代移植の成功とその病理像
• フミノビリンおよびその分子化合物の催奇性
• ウレタン誘発奇形に対する 13-trans-retinoic acid の抑制効果 : 関西支部 : 第33回日本肺癌学会関西支部会
• 化学発がん物質による肺腫瘍発生と催奇性の初期過程の類似性
• Nitrofurazoneのマウス胎仔及び新生仔に対する作用
• ヒト臓器・組織置換マウスを用いた薬物評価系
• 343 VIN III(外陰扁平上皮内癌)における多発性病変のクロナリティ解析
• HTLV-IトランスフォームヒトT細胞のNK活性保有SCIDマウスへの移植(短報)
• 放射線の次世代への影響
• Programmed Cell Death in Whole Body and Organ Systems by Low Dose Radiation
• Paternal Exposure to Radiation and Offspring Cancer in Mice: Reanalysis and New Evidences
• SCID (Severe Combined Immunodeficiency) Mice as a New System to Investigate Metastasis of Human Tumors
• がんと奇形の発生(特別講演II, 第24回日本小児外科学会総会)
• がんと奇形の発生
• 癌の遺伝的要因--癌化における突然変異の重要性
• 受精直後の母体への処置による発生障害 : 特に受精前から着床までの時期における処置による発生障害について
• 発癌因子の垂直伝達(綜説シリ-ズ--現代医学の焦点-53-)
• 20. 奇形,癌,突然変異誘発の分子機構の類似性
• A mechanism underlying STAT4-mediated up-regulation of IFN-γ induction in TCR-triggered T cells
• Reversible CD8 expression induced by common cytokine receptor γchain-dependent cytokines in a cloned CD4^+ T_h1 cell line
• Requirement of IFN-γ in IL-12 production induced by collaboration between V_α14^+ NKT cells and antigen-presenting cells
• CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism
• Assignment of Six Patients with Xeroderma Pigmentosum in Hokkaido Area to A Variant Form
• 1,3-di-(4-sulfamoylphenyl)-triazene の妊娠マウス投与による子孫での細網リンパ腫の誘発 : 関西支部 : 第33回日本肺癌学会関西支部会
• Analysis of p53, K-ras, c-kit, and β-catenin genemutations in sinonasal NK/T cell lymphoma in northeast district of China
• Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-respomsive versus-unresponsive tumor models
• MOLECULAR MECHANISMS UNDERLYING T CELL MIGRATION RESPONSIBLE FOR IL-12-INDUCED TUMOR REGRESSION
• Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12
• Oncogenic osteomalacia secondary to nasal tumor with decreased urinary excretion of cAMP
• A Novel SCID Technology for Biomedical Studies in Human Tissues
• B cell-mediated down-regulation of IFN-γ and IL-12 Production induced during antitumor immune responses in the tumorbearing state
• マウスにおける抗菌物質の胎仔毒性
• Functional and Morphological Abnormalities of Mitochondria in Human Cells Containing Mitochondrial DNA with Pathogenic Point Mutations in tRNA Genes
• Radiation-induced Mutations in Human Thyroid Tissues Maintained in the Improved SCID Mice.
• Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association
• Inhibition of Growth and Metastasis of Ovarian Carcinoma by Administering a Drug Capable of Interfering with Vascular Endothelial Growth Factor Activity
• アミノビリンの催奇性に対するバルビタールおよびフェノバルビタールの促進効果
• UrethanによるマウスのTeratogenesisとCarcinogenesis : ヒト環境変異原と催奇形因子
• A Defect in Cell-to-cell Adhesion via Integrin-Fibronectin Interactions in a Highly Metastatic Tumor Cell Line
• Do Structural Changes of T Cell Receptor Complex Occur in Tumor-bearing State?
• Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
• Mutation analysis of Japanese patient with fucosidosis
• Nasal NK/T-cell lymphoma : epidemiology and pathogenesis
• Gene Mutations in Second Malignancies after Radiotherapy
• Mutations of p53, c-kit, K-ras, and β-Catenin Gene in Non-Hodgkin's Lymphoma of Adrenal Gland
• Microsatellite Instability and k-ras, p53 Mutations in Thyroid Lymphoma
• p53 mutations in patients with pyothorax associated lymphoma(PAL).
• Induction of Sister Chromatid Exchanges by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Cultured Mammalian Cells
• Thermoelectric Properties of NaCo_Cu_xO_4 Improved by the Substitution of Cu for Co : Structure and Mechanical and Thermal Properties of Condensed Matter
• Overexpression of the Wilms′tumor gene WT1 in head and neck squamous cell carcinoma
• Translocation of tyrosine-phosphorylated TCRζ chain to glycolipid-enriched membrane domains upons T cell activation
• マウス胎児肺のウレタン感受性
• The Characteristics of the New Display Device Using the Depolarization of a Liquid Crystal (DTN-cell) : B-7: OPTICAL DEVICES (2)
• Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET : a comparison with CT and endoscopic findings
• EFFECTS OF CHOLINERSTERASE INHIBITORS ON NEUROTRANSMITTER METABOLISM IN THE BRAIN
• ALLELE FREQUENCIES OF INTRAGENIC, AND 5' AND 3' MARKERS OF THE DYSTROPHIN GENE IN JAPANESE FAMILIES AFFLICTED WITH DUCHENNE OR BECKER MUSCULAR DYSTROPHY
• Rhodium-Catalyzed Si-F Exchange Reaction between Fluorobenzenes and a Disilane.Catalytic Reaction Involving Cleavage of C-F Bonds
• 中国河南林県における食道癌高発の原因究明と予防
• Estimation of the Environmental Value of Recycled Wood Wastes : A Conjoint Analysis Study
• Clinical experiences in Sakai City Hospital during the massive outbreak of enterohemorrhagic Escherichia coli O157 infections in Sakai City, 1996
• Hunting, Wildlife Management and the Federal Hunting Act in Germany

もっと見る 閉じる

スポンサーリンク