アミノビリンの催奇性に対するバルビタールおよびフェノバルビタールの促進効果

概要

論文の詳細を見る
Aminopyrine and its molecular compound with barbital (Pyrabital) showed potent teratogenicity, whereas an equivalent dose of its molecular compound with cyclobarbital (Cyclopyrabital) showed very weak teratogenicity. Even if aminopyrine was given subcutaneously to the right flank of pregnant mice and barbital given to the left flank at the same time on days 9,10 and 11 of gestation, teratogenicity was approximately equal to that by the equivalent dose of molecular compound, but significantly higher than that of aminopyrine alone. When barbital was given as a suspension in 1% gelatin solution, it strongly enhanced aminopyrine-initiated teratogenesis, while cyclobarbital did not. Barbital might induce an enzyme responsible for transforming aminopyrine to teratogenic forms, since pre-treatment of aminopyrine with barbital on days 5,6,and 7 significantly enhanced teratogenicity initiated by aminopyrine. Pre-treatment with phenobarbital also enhanced aminopyrine-initiated teratogenesis, while it did not enhance X-ray-initiated one.
公益社団法人日本薬学会の論文
1981-05-25