The Radioprotective Effect against Gamma-lrradiation of Methylene Blue in the Rat with Reference to Serum Enzymes and Pancreatic Protein Fractions Examined by Isoelectric Focussing
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概要
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The Sprague-Dawley male rats were given 360 rads of single whole-body gamma-irradiation following an intraperitoneal injection of methylene blue (40 mg/kg). Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum amylase, serum lipase, and serum lecithinase A activities, and isoelectric focussing pattern of pancreatic juice proteins were determined at various time intervals after exposure. Methylene blue reduced generally the rise of SGOT, SGPT, amylase, and lipase activities. Methylene blue delayed also the serum lecithinase A fall after exposure. Mean number of protein bands as revealed by isoelectric focussing of poncreatic juice were significantly altered in both the control and the methylene blue-treated group after exposure. Especially methylene blue-treated group showed a marked delay in the decrease in number of protein bands after exposure. The possibility of using the SGOT, the SGPT, the serum amylase, the serum lipase, and the serum lecithinase A levels, and the number of protein bands in isoelectric focussing pattern of pancreatic juice as an early index of radiation injury is suggested.
- 日本放射線影響学会の論文
著者
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Nam Sang
Department Of Biochemistry College Of Pharmacy Kyung-hee University
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Nam Sang
Department Of Biology Graduate School Kyung Hee University
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CHUNG SE
Department of Biology, Graduate School, Kyung Hee University
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Chung Se
Department Of Biology Graduate School Kyung Hee University
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- The Radioprotective Effect against Gamma-lrradiation of Methylene Blue in the Rat with Reference to Serum Enzymes and Pancreatic Protein Fractions Examined by Isoelectric Focussing
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