Immunological Correlation of Several Neurogenic Tumors and Mammary Carcinoma in a Syngeneic Rat System
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概要
- 論文の詳細を見る
Immunological cross-reactivities between rat spontaneous mammary carcinoma or ethylnitrosourea (ENU)-induced neurogenic tumors and various fetal and adult tissues were tested in vitro by the migration inhibition test (MIT). Wistar/Fib rats were immunized with either live cells or radiation-killed tumor cells of over 37 transplant generations. ENU-induced neurinomas of the peripheral nerve (T1, T3) lost some of their antigenicities in the later transplantation generations, and failed to react with fetal or brain tissues. On the other hand, ENU-induced oligodendroglioma (T5) retained strong antigenicities at least up to the 10th passage. In addition, T5 and syngeneic spontaneous mammary carcinoma (T9) showed similar responses to fetal extracts. Among the tissues examined, two-week fetal tissues showed the highest expression of fetal antigens detected by cross-reaction with these tumor cells. MIT with 3M KCl extracts of fetal tissues demonstrated that sensitization with live tumor cells elicited stronger immunological responses than that with radiation-killed cells.
- 日本脳神経外科学会の論文
- 1980-07-15
著者
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HANDA Hajime
Department of Neurosurgery, Kyoto University Medical School
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Handa Hajime
Department Of Neurosurgery And Pharmacology Faculty Of Medicine Kyoto University
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TOKURIKI Yasuhiko
Department of Neurosurgery, Fukui Red Cross Hospital
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Tokuriki Yasuhiko
Department Of Neurosurgery Kyoto University Medical School
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Tokuriki Yasuhiko
Department Of Neurosurgery Fukui Red Cross Hospital
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ODA Yoshifumi
Department of Neurosurgery, Kyoto University Medical School
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KIELER Jorgen
The Fibiger Laboratory, sponsored by the Danish Cancer Society
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Kieler Jorgen
The Fibiger Laboratory Sponsored By The Danish Cancer Society
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Oda Yoshifumi
Department Of Neurosurgery Kyoto University Medical School
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Oda Yoshifumi
Department Of Neurosurgery Kobe City General Hospital
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