イソフラボン含有サプリメントの過剰摂取により子宮筋腫の増大と子宮内膜増殖症がみられた閉経後婦人の1例

概要

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A postmenopausal patient with enlarged uterine myomas and endometrial hyperplasia, who overingested isoflavone 3 years previously, is described. The patient was a 64-year-old Japanese woman, gravida 2, para 0. After she moved to Hawaii at 61-year-old, she ingested both soybean protein and supplement containing isoflavone everyday. Total amount of isoflavone was estimated to be beyond 120mg per day. Three years later, she complained of genital bleeding following breast spanning. She was diagnosed with enlarged uterine myomas and underwent abdominal hysterectomy and bilateral salpingo-oophorectomy. Histological examination revealed a submucous and an intramural leiomyomas and simple endometrial hyperplasia without atypia. Overingesting isoflavone may result in these gynecologic disorders.
社団法人日本産科婦人科学会の論文
2002-12-01