マイクロサテライト領域遺伝子異常を示した同時性4重複癌の1例

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We report a 47-year-old Japanese woman who was diagnosed with hereditary non-polyposis colorectal carcinoma and synchronous quandruple cancer of the endometrium, ovary, cervix and sigmoid colon. Her mother, elder sister, grandmother and two aunts had all been diagnosed with uterine cancer. Another elder sister had a past, history of colon cancer. Our patient underwent a modified redical hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, omentectomy, appendectomy, sigmoidectomy, and intraperitoneal administration of carboplatin. Subsequently, she received 3 courses of cyclophosphamide, adriamycin and cisplatin. We analyzed microsatellite instability (MI) by using the DNA of the ovarian tumor tissue and found MI positive. The patient remains alive without evidence of redurrence 25 months postoperatively.
社団法人日本産科婦人科学会の論文
2001-07-01