THE INDUCTION OF OVULATION BY SMALL DOSE AND LONG TERM ADMlNISTRATION OF CLOMIPHENE

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概要

• 論文の詳細を見る

• 概要50mgのclomiphene5日間3回くり返し投与しても排卵が認められなかった28例の続発性無月経の患者にclomiphene 50mg14日投与したところ9例に排卵を認めた.これらの排卵例は1例を除いてprogeste-rone投与後所謂消退性出血が認められたもので,ある程度の内因性estrogenの産生が必要であることを示すものである.またいくつかの症例についてclomiphene投与前後の血中LH,FSH,estrogen,progesterone値を測定した.排卵した症例ではclomiphen投与中LH,FSH,estrogenが増加したが特にestrogenの増加が著明であった.一方これら症例についてLHRHによる下垂体の反応とこのclomiphene投与法による排卵誘発との関係について検討した.排卵例では無排卵例に比べてLHRH投与後のLHとFSHのnet inccreaseが有意に大きかったがpercent increaseには差がなかった.さらに卵巣摘出後の婦人にclomlpheneを投与してもLHとFSHの増加がみられなかったことよりclomipheneの作用機序は視床下部-下垂体系におけるestrogenとの競合が強く示唆された.

• 社団法人日本産科婦人科学会の論文
• 1979-10-01

著者

• SUZUKI AKIRA

  Department of Hospital Pharmacy

• KUMASAKA Takahiro

  Department of Obstetrics and Gynecology, Dokkyo University School of Medicine

• Kumasaka Takahiro

  Department Of Obstetrics Aud Gynecology School Of Medicine Tokyo Medical And Dental University Tokyo

• EN Nobuyoshi

  Department of Obstetrics aud Gynecology, School of Medicine, Tokyo Medical and Dental University, To

• YAOI Yoshimasa

  Department of Obstetrics aud Gynecology, School of Medicine, Tokyo Medical and Dental University, To

• SAITO Motoi

  Department of Obstetrics aud Gynecology, School of Medicine, Tokyo Medical and Dental University, To

• Saito Motoi

  Department Of Obstetrics Aud Gynecology School Of Medicine Tokyo Medical And Dental University Tokyo

• En Nobuyoshi

  Department Of Obstetrics Aud Gynecology School Of Medicine Tokyo Medical And Dental University Tokyo

• Yaoi Yoshimasa

  Department Of Obstetrics Aud Gynecology School Of Medicine Tokyo Medical And Dental University Tokyo

• Suzuki Akira

  Department Of Biology Faculty Of Education Chiba University

• Suzuki Akira

  Department Of Anesthesiology And Intensive Care Hamamatsu University School Of Medicine

• Suzuki Akira

  Department Of Obstetrics Aud Gynecology School Of Medicine Tokyo Medical And Dental University Tokyo

• SAITO MOTOI

  Department of Obstetrics and Gynecology, Tokyo Medical and Dental University

• 熊坂 高弘

  Department of Obstetrics aud Gynecology, School of Medicine, Tokyo Medical and Dental University, Tokyo

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