免疫性不妊症からみた受精機構に関与する因子の同定とその利用(1 受精機構とその異常)

概要

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Antisperm antibodies can cause infertility by interferring with human fertilization process. We have demonstrated the inhibitory effect of antisperm antibodies on acrosome reaction of sperm, an indispensable event for successful fertilization. The inhibitory effects of the antibodies on the acrosome reaction may be explained by their blocking effects on capacitation through inhibiting an increase of fluidity of the spermmembrane. After binding of sperm onto the surface of zona pellucida, interaction of mannose-receptor of the sperm and mannose molecule on the zona pellucida is an essential step for sperm penetration through the zona pellucida. The finding that antisperm antibodies do not appear to cause any deleterious clinical symptoms and yet be associated with infertility suggested that sperm antigens are promising candidates in the develpment of immunocontraceptives. Some synthetic peptides corresponding to segments of human sperm antigens can effectively induced infertility in female rats when administeresd as an immunogen. The method of mucosal immunization using cDNA coding the sperm antigens is promising breaktroughs in the strategy of developing an effective antifertility vaccine.
社団法人日本産科婦人科学会の論文
2001-09-01