Bioflavonoid apigeninの抗酸化作用によるラット卵成熟抑制効果

概要

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We previously showed that cell permeant antioxidants inhibit spontaneous germinal vesicle break down (GVBD) in rat oocyte-cumulus complexes (OCC). As bioflavonoid apigenin is known to be an antioxidant, we assessed whether apigenin inhibits spontaneous GVBD in OCC. Spontaneous GVBD in rat OCC was significantly inhibited by the minimum effective dose of 10μM apigenin. Moreover, incubation of OCC with 2, 2'-azobis (2-amidinopropane)dihydrochloride (AAPH) that is known to generate radicals in aqueous media reversed the inhibition of GVBD produced by 100μM apigenin. These findings support the conclusion that apigenin inhibits oocyte maturation by acting as an antioxidant.
社団法人日本産科婦人科学会の論文
2000-03-01