マウス神経芽腫(C1300)における免疫応答機構の解析

概要

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Immune response to mouse neuroblastoma (C1300) was analysed in this report. Cell-mediated immune reactivity of A/J mouse spleen cells to syngeneic neuroblastoma cells was studied by using antibody-dependent cell-mediated cytotoxicity (ADCC), natural killer (NK) and killer T activity. The results are summarized as follows: 1. NK activity of A/J spleen cells to C1300 demonstrated quite low grade irrespective of age. 2. Killer T activity could be induced by innoculation of C1300 to syngeneic A/J mouse. The activity was time-dependent and gradually increased by week 2 and then decreased by week 4. 3. The time course of killer T activity coincided with that of host tumor viability. 4. Rabbit anti-Cl300 antibody could be obtained by subcutaneous injection of C1300(2x10_7 cells). The specificity was satisfactory by testing, with complement-dependent cytotoxicity and immunofluorescence technique.
日本小児外科学会の論文
1981-06-20