5 ブラシノステロイド生合成阻害剤の立体構造と活性の相関及び作用部位について

概要

論文の詳細を見る
Brassinozole is a specific brassinosteroid (BR) biosynthesis inhibitor and is shown to be useful to elucidate the function of BRs. In the course of Structure-activity relationship study on brassinazole, we found more specific and potent BR biosynthesis inhibitors Brz2001 and Brz220, each of which consist of 4 isomers. Generally, azole derivatives showed different activity in response to their stereoisomers. Therefore we separated Brz2001 and Brz220 into 4 isomers on silica gel HPLC and chiral column, respectively, and tested their ability to inhibit BR biosynthesis. The biological activity of these compounds was evaluated by cress stem elongation test. The activity of their compounds clearly depend on their stereostructure. In care of Brz220, the absolute structure of each stereoisomer was determined by the combination of chemical synthesis and NMR analysis.
植物化学調節学会の論文
2001-10-09