INFLUENCE OF PTAQUILOSIDE ON THE DEVELOPMENT OF NEWBORN MICE
スポンサーリンク
概要
- 論文の詳細を見る
We attempted to induce neurological disorders in mice by a single administration of various doses of ptaquiloside (PT) within 24 h after birth. Animals which survived for a long period after treatment showed a reduction in body weight, but did not develop any gait disturbance. On the other hand, in treated animals which died before beginning to walk, karyorrhexis in the external granular layer of the cerebellum and karyorrhexis and rosette formation in the neuroblastic layer of the retina were present. In addition, treated animals showed karyorrhexis and great reduction in the number of the cells in the thymus, suggesting cytotoxic and cytolytic effects of alkylating agents on lymphocytes in this organ.
- 日本トキシコロジー学会の論文
- 1987-05-25
著者
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HIRONO Iwao
Department of Pathology, Fujita-Gakuen University School of Medicine
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OGINO Hiroshi
Department of Chemistry, Graduate School of Science, Tohoku University
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Ogino H
Department Of Chemistry Graduate School Of Science Tohoku University
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FUJIMOTO Masao
Department of Internal Medicine, Tono Kosei Hospital
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Ogino Hiroshi
Department Of Pathology Fujita-gakuen Health University School Of Medicine
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Ogino Hiroshi
Department Of Chemistry Faculty Of Science Tohoku University
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Hirono Iwao
Department Of Carcinogenesis And Cancer Susceptibility Institute Of Medical Science University Of To
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Hirono Iwao
Department Of Pathology Fujita-gakuen Health University School Of Medicine
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Fujimoto Masao
Department Of Pathology Fujita-gakuen Health University School Of Medicine
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Fujimoto Masao
Department Of Internal Medicine Ja Gifu Tohno-kousei Hospital
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