COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 20)TESTICULAR TOXICITY OF NITROFURAZONE AFTER 2 AND 4 WEEKS
スポンサーリンク
概要
- 論文の詳細を見る
Nitrofurazone (NF) has been previously demonstrated to induce testicular toxicity with 4 weeks of oral administration in rats. In the present study, rats were administered NF to assess whether testicular toxicity becomes evident with a 2-week administration period. Male Sprague-Dawley rats were administered oral doses of NF at 50 mg/kg for 2 or 4 weeks. Another group was administered NF at 100 mg/kg for 2 weeks. The control animals received the vehicle (0.5% methylcellulose) for 4 weeks. Organ weights of the testis and epididymis were significantly decreased in all NF-administered animals, and seminiferous tubules were severely atrophied, due to a total absence of spermatids and degeneration and desquamation of spermatocytes. In the epididymis, decreased numbers of spermatozoa were evident in the ducts. In rats that were administered NF at 50 mg/kg, the changes in the epididymis in the 2-week group were less prominent than those in the 4-week group. In the testis, however, the changes were similar in both groups. Thus it was demonstrated that NF-induced testicular toxicity comparable to that observed after 4 weeks of administration is also detectable after 2 weeks.
- 日本トキシコロジー学会の論文
- 2000-10-25
著者
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Shimo T
National Inst. Health Sci. Tokyo
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Ito K
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Ito Kohzo
Graduate School Of Frontier Sciences University Of Tokyo
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NII Aisuke
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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ITO Kyoko
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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OKAMIYA Hideaki
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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SAKAI Toshiharu
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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SHODA Toshiyuki
National Institute of Health Sciences
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Sakai Toki
Toxicology Laboratory Pharmaceutical Development Department Meiji Seika Kaisha Ltd.
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Shoda Toshiyuki
Yamanouchi Pharmaceutical Co. Ltd.
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Sakai Toshiharu
Safety Research Laboratories Product Development Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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伊藤 今日子
Medicinal Safety Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Ito K
Drug Safety Research Laboratories Astellas Pharma Inc.
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Nii Aisuke
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
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Sasaki Satoru
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Sakai T
Yamanouchi Pharmaceutical Co. Ltd.
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YOSHIDA Kohsuke
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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Okamiya Hideaki
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Okamiya Hideaki
Safety Research Laboratories Product Development Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Yoshida Kohsuke
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Nii Aisuke
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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伊藤 今日子
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Ito Kyoko
Safety Research Laboratories, Yamanouchi Pharmaceutical Co Ltd.
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NII Aisuke
Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Inc.
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ITO Kyoko
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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