Localization of Endothelin Receptor Subtype-A in the Testis of Rats, Dogs, and Monkeys
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概要
- 論文の詳細を見る
In order to evaluate the physiological roles of the testicular endothelin (Edn) signaling via Edn receptor subtype-A (Ednra) in mammals, the localization of Ednra was investigated by in situ hybridization and immunohistochemistry in the testis of rats, dogs, and monkeys. For in situ hybridization, a rat Ednra RNA probe which is highly homologous to the subcloned canine and monkey Ednra (88.7% and 87.9% identical, respectively) was used. Both Ednra mRNA and protein were detected in interstitial cells and cells in the basal compartment of the seminiferous tubules, mainly Sertoli cells, as well as spermatogonia and some early spermatocytes, but not spermatids. The localization pattern of Ednra was exhibited in a same manner among species, indicating that the physiological role of Edn signaling throughout Ednra was maintained in the mammalian testis.
- 公益社団法人 日本獣医学会の論文
著者
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Nakano Kenji
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Okada Akinobu
Safety Research Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd
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Fujiwara Michio
Safety Research Laboratories Yamanouchi Pharmaceutical Col Ltd
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ITO Kyoko
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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FUJIWARA Michio
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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SHISHIDO Takao
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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NAKANO Kenji
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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TAMURA Kotaro
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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OKADA Akinobu
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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