PROTEIN-MEDIATED TRANSFER OF DDT TO ADIPOSE TISSUE
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概要
- 論文の詳細を見る
The in vitro transfer of DDT through various media to rat adipose tissue was examined. About 15% of DDT was transferred through Krebs-Ringer solution to the tissue slices after 2-hr incubation at 37℃. The addition of albumin accelerated the transfer of DDT proportionally to the concentrations up to 1.0 %. Hemoglobin and γ-globulin showed a lesser accelerating activity, but protamine, trypsin and pepsin showed little or no effect. When the Krebs-Ringer solution was replaced by triglyceride suspensions, only a small amount of DDT was taken up by the adipose tissue. Ffflux experiments revealed that the adipose tissue scarcely released DDT into albumin solution or triglyceride suspensions. The results suggest that lipid may play an important role as a storage site of DDT and that albumin may behave as a carrier system.
- 日本トキシコロジー学会の論文
- 1978-02-15
著者
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Koga Kenichi
Department Of Phamacology Sapporo Medical College
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Koga Kenichi
Department Of Electronics And Computer Science College Of Science And Technology Nihon University
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Ohmiya Yoshio
Department Of Pharamacology Akita University School Of Medicine
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