POTENTIATION OF TOLUENE TOXICITY BY HEPATIC ENZYME INHIBITION IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
The toxicity of toluene was evaluated in male mice by the narcotic effects and lethality. The i.p. LD_<50> of toluene for male mice was calculated to be 1.15g/kg according to the method of Weil. Pretreatment with phenobarbital, produced a marked decrease in the number of sleep induced by a test dose (0.96 g/kg i.p.) of toluene. By contrast, pretreatment with a variety of hepatic enzyme inhibitors such as CCl_4, SKF 525A, pyrazole and cyanamide was found to produce an increase in the number of sleep and death, accompanied with the prolongation of sleeping time. The present results suggest that the toxicity of toluene is enhanced by the inhibition of any step of metabolism. Toluene is an organic solvent which has been used widely in industry and is contained in thinner as its major constituent.
- 日本トキシコロジー学会の論文
- 1978-02-15
著者
-
OHMIYA Yoshio
Department of Pharamacology, Akita University School of Medicine
-
Koga Kenichi
Department Of Physics Kumamoto University
-
Koga Kenichi
Department Of Pharmacology Sapporo Medical College
-
Koga Kenichi
Department Of Electronics And Computer Science College Of Science And Technology Nihon University
-
Ohmiya Yoshio
Department Of Pharamacology Akita University School Of Medicine
関連論文
- HEMOLYTIC EFFECTS AND BINDING BY ERYTHROCYTES OF BENZYL ALCOHOL (The Fourth Meeting for the Study of Toxic Effect)
- 102. Deformation of Surface Structure of Erythrocytes Induced by Mercurials (The Second Meeting for the Study of Toxic Effect)
- A Consideration on Numerical Processing of the Cross-Correlation Method for Extremely Low Phase Noise Measurement
- A13 MEMBRANE PERTURBATION OF RAT LUNG MICROSOMES AND CHANGES OF GSH LEVELS BY MAINSTREAM AND SIDESTREAM SMOKE
- NMR study on K2CuF4 at Milikelvin Temperatures
- POTENTIATION OF TOLUENE TOXICITY BY HEPATIC ENZYME INHIBITION IN MICE
- EFFECTS OF Hg^ ON ACCUMULATION AND METABOLISM OF CHLORPROMAZINE AND IMIPRAMINE BY THE RAT LUNGS
- PROTEIN-MEDIATED TRANSFER OF DDT TO ADIPOSE TISSUE
- EFFECTS OF GLUCOCORTICOID ON RELEASE OF ANGIOTENSIN CONVERTING ENZYME FROM THE DRUG-DAMAGED LUNG
- INTERACTION OF BENZYL ALCOHOL WITH HUMAN ERYTHROCYTES
- RELATIONSHIP BETWEEN INHIBITION OF MEMBRANE SH GROUPS AND HEMOLYSIS INDUCED BY SH INHIBITORS
- METHYLMERCURY-INDUCED HEMOLYSIS AND BINDING OF THE MERCURY BY ERYTHROCYTE MEMBRANE
- EFFECT OF CARBON TETRACHLORIDE ON ETHANOL METABOLISM
- EFFECT OF METHYLMERCURY ON THE ETHANOL ELIMINATION FROM THE BLOOD AND THE ACTIVITY OF ALCOHOL DEHYDROGENASE
- INFLUENCE OF AMINO ACIDS ON UPTAKE OF CADMIUM BY KIDNEY AND BRAIN CORTEX SLICES (The 5th Meeting for the Study of Toxic Effect)
- Spontaneous Magnetization of Two Dimensional Ferromagnetic at Millikelvin Temperature
- Glomerular Endotheliosis in a Pregnant Woman with Severe Gestational Proteinuria