INTERACTION OF BENZYL ALCOHOL WITH HUMAN ERYTHROCYTES
スポンサーリンク
概要
- 論文の詳細を見る
The uptake of benzyl alcohol by human erythrocytes and its binding to cell membranes were examined <I>in vitro</I> in relation to its hemolytic actions. The hemolysis induced by benzyl alcohol was found to be time-, dose- and temperaturedependent. Little or no hemolysis was observed until the concentration of benzyl alcohol increased over a certain level. Radiotracer studies revealed that in contrast to the rapid cellular uptake which was independent of temperature, the binding of benzyl alcohol to membranes increased gradually with time and was dependent mainly on the temperature. The critical hemolytic levels of the alcohol bound to membranes were estimated to be about 500 nmoles/mg protein. The results obtained herein suggest that the process of hemolysis induced by benzyl alcohol depends on the binding of the alcohol to erythrocyte membranes.
- 社団法人 日本薬理学会の論文
著者
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Nakai Kengo
Department Of Pharamacology Akita University School Of Medicine
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Ohmiya Yoshio
Department Of Pharamacology Akita University School Of Medicine
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