METHYLMERCURY-INDUCED HEMOLYSIS AND BINDING OF THE MERCURY BY ERYTHROCYTE MEMBRANE
スポンサーリンク
概要
- 論文の詳細を見る
Binding of methylmercury by human erythrocyte membranes was examined in association with the mercury-induced hemolysis. Organic mercurials such as p-chloromercuribenzoate and methylmercury showed less potent hemolytic activity than HgCl_2. Entry of methylmercury into the erythrocytes was very rapid. Over 95 % of methylmercury was taken up by the cells within 5 min over the concentration range studied. Percent binding by the membrane of methylmercury was lower than HgCl_2. Affinity of the intact membranes as well as of the isolated membranes was found to be lower for methylmercury than for HgCl_2. Analysis by means of the Scatchard plot indicated a variety of binding sites of the erythrocyte membranes for the mercurials. The critical level of methylmercury required for hemolysis was about 200 nmole/mg membrane protein. No close correlation was observed between membrane sulfhydryl inhibition and hemolysis. The results presented here suggested that affinity of the erythrocyte membranes for the mercuials is one of the determining factors in hemolysis.
- 日本トキシコロジー学会の論文
- 1977-04-15
著者
-
Ohmiya Yoshio
Department Of Pharamacology Akita University School Of Medicine
-
Ohmiya Yoshio
Department Of Pharmacology Akita University School Of Medicine
関連論文
- HEMOLYTIC EFFECTS AND BINDING BY ERYTHROCYTES OF BENZYL ALCOHOL (The Fourth Meeting for the Study of Toxic Effect)
- 102. Deformation of Surface Structure of Erythrocytes Induced by Mercurials (The Second Meeting for the Study of Toxic Effect)
- A13 MEMBRANE PERTURBATION OF RAT LUNG MICROSOMES AND CHANGES OF GSH LEVELS BY MAINSTREAM AND SIDESTREAM SMOKE
- POTENTIATION OF TOLUENE TOXICITY BY HEPATIC ENZYME INHIBITION IN MICE
- EFFECTS OF Hg^ ON ACCUMULATION AND METABOLISM OF CHLORPROMAZINE AND IMIPRAMINE BY THE RAT LUNGS
- PROTEIN-MEDIATED TRANSFER OF DDT TO ADIPOSE TISSUE
- EFFECTS OF GLUCOCORTICOID ON RELEASE OF ANGIOTENSIN CONVERTING ENZYME FROM THE DRUG-DAMAGED LUNG
- INTERACTION OF BENZYL ALCOHOL WITH HUMAN ERYTHROCYTES
- RELATIONSHIP BETWEEN INHIBITION OF MEMBRANE SH GROUPS AND HEMOLYSIS INDUCED BY SH INHIBITORS
- METHYLMERCURY-INDUCED HEMOLYSIS AND BINDING OF THE MERCURY BY ERYTHROCYTE MEMBRANE
- EFFECT OF CARBON TETRACHLORIDE ON ETHANOL METABOLISM
- EFFECT OF METHYLMERCURY ON THE ETHANOL ELIMINATION FROM THE BLOOD AND THE ACTIVITY OF ALCOHOL DEHYDROGENASE
- INFLUENCE OF AMINO ACIDS ON UPTAKE OF CADMIUM BY KIDNEY AND BRAIN CORTEX SLICES (The 5th Meeting for the Study of Toxic Effect)