徐放性ニフェジピン細粒製剤 (KB-1712P) の溶出挙動に制酸剤の同時投与が与える影響

概要

論文の詳細を見る
When sustained release preparations, featuring a pH-dependent dissolution, are used concomitantly with medication containing antacids, the possibility exists of adverse effects being generated on the sustained release action. We thus studied the dissolution of nifedipine when sustained-release nifedipine granules (KB-1712P) were administered concomitantly with widely used antacids, using a modified Fuchs method which simulated the mechanism in the body. The results showed that the dissolution rate of nifedipine tended to increase when it was administered concomitantly with sodium bicarbonate or Maalox^<[◯!R]> with a neutralization endpoint in a 0.1N-HCl at a pH of at least 6. However, no effects on the dissolution rate were seen when SM-Powder^<[◯!R]> with a low content of sodium bicarbonate or Kolantyl Granules^<[◯!R]> exhibiting with a neutralization endpoint at pH 4 was administered. These results suggest that it is necessary to administer sodium bicarbonate or Maalox^<[◯!R]> at different times when they are used concomitantly with sustained-release nifedipine granules.
日本医療薬学会の論文
1994-06-20