ポビドンヨード含嗽剤の退色と殺菌力減少の相関性

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A relationship between color fading and decrease of disinfectant activity of Povidone-Iodine (PVP-1) gargle was examined. A linear correlation between the absorbance at 550 nm and the concentration of free iodine (I_2) was confirmed. Furthermore, a good correlation was observed between the bactericidal activity and the concentration of the free I_2, though only with in the narrow range, 0.063-0.148 mg/ml of free I_2 concentrations. The PVP-1 gargle containing free I_2 at the concentration of 0.131 mg/ml exhibited sufficient bactericidal activity in vitro, nevertheless it was a colorless liquid to the naked eyes. These results suggest that whether or not the disinfectant activity of PVP-1 gargle still remains in the proper solution should be estimated on the basis of the exact concentration of free I_2, not on the basis of a degree of the brownish color of the solution.
1985-12-20

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