含嗽用Povidone Iodine希釈液の遊離ヨウ素濃度及び殺菌効果におよぼす保存温度の影響

概要

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Concentrations of free iodine in dilute solutions of povidone-iodine (PVP-I) gargle and its bactericidal activity were examined during 21 days of storage at various temperatures. Free iodine was reduced a little when 15〜30-fold dilute solutions were stored for 21 days in a dark place at 5°. On the other hand free iodine in a 30-fold dilute solution was reduced extremely and its residual rate of iodine was around 50% on 21 days after it was stored in a dark place at 35°. Reduction of free iodine was found to be dependent on temperature. However, the 30-fold dilution of PVP-I gargle stored at 35°kept sufficient bactericidal activity for Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas cepacia, Pseudomonas aeruginosa, Streptococcus pyogenes and Esherichia coli even after the storage for 21 days. Further, salivary bacteria were killed by 60-fold dilute solution of PVP-I gargle, as well as by 30-fold. These findings indicate that 15〜30-fold dilute solutions of the PVP-I gargle are effective for 3 weeks if they are stored under 5°, and its 60-fold solution has a sufficient bactericidal effect in the mouth.
日本医療薬学会の論文
1986-06-20