ニフェジピン製剤の品質試験

概要

論文の詳細を見る
The quality of 3 kinds of tablets and capsules of commercial nifedipine preparations was evaluated in 5 tests : content uniformity, weight variation, disintegration, hardness and dissolution. Following results were obtained; 1) In the weight variation test and the disintegration test, all the preparations tested met the criteria of J.P. X. 2) There was no correlation between hardness and disintegration time. 3) In the content uniformity test, the mean contents of all preparations tested were almost equal to the indicated content; however, in one preparation p-hydroxybenzoic acid derivatives added to the capsule were dissolved in the contents and interfered with the determination of nifedipine under the analytical condition applied to the others. Consequantly, it was necessary to find another analytical condition for this preparation. 4) The dissolution ratios of 5 kinds of preparations were good, but that of one tablet showed low tendency compared with those of the others at every measurement.
日本医療薬学会の論文
1983-12-20