ミノサイクリンの吸収におよぼす子羊胃粘膜エキスとクエン酸の影響

概要

論文の詳細を見る
The influence of the extract of lamb's gastric mucosa and citric acid on absorption of minocycline hydrochloride (MC-HC1) from the gastrointestinal tract was investigated after oral administration to humans. Serum and urine levels of MC-HC1 were determined by thin layer horizontal diffusion method with Bacillus subtilis PCI-219. Each gram of the preparation used in this experiment contains 200mg of the extract of lamb's gastric mucosa, 5mg of citric acid, 10μg of cyanocobalamin and lactose as excipient ; in addition, 15μg of zinc was also detected. The absorption of MC-HC1 given in dose of 200mg was apparently inhibited by a single administration of this preparation (1g) or concomitant use of 200mg of citric acid at the rate of 36.4% and 41.9%, respectively, 2 hours after administration. The action mechanism is not clear, but the absorption of MC-HC1 was not inhibited at all by concomitant administration of this preparation and 5mg of citric acid.
日本医療薬学会の論文
1978-05-20