グリセオフルビン製剤の溶出と吸収

概要

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Dissolution and absorption of 2 brands of griseofulvin preparation (A and B) and an improved form of the preparation B(C) were compared. Dissolution test was made by using Sartorius Solubility Simulator. As an elute, about 30% ethanol solution was used, because griseofulvin is insoluble in water. Amount of griseofulvin was determined by HPLC. Absorption study was made using rabbits. Plasma concentration of griseofulvin was determined by spectrofluorometer. The following results were obtained : 1) In dissolution test, 50% dissolution time of preparations A, B and C were 49 min, 63 min and 37 min, respectively. Dissolution rate at 120 min was high in the order. C>A>B ,where the rate of C was significantly higher than that of the other 2.2) In absorption test, plasma concentration of A reached its maximum in 8 hours after administration, but that of the other 2 in 6 hours. Plasma concentration of B was generally lower than those of the others.
日本医療薬学会の論文
1984-02-20