消化酵素剤のリパーゼ活性におよぼす胆汁酸の影響

概要

論文の詳細を見る
It has been widely known that bile acids increase lipase activity, and the lipase activity of various digestive enzyme preparations has been reported. Clinically, bile acids have often been administered in combination with digestive enzyme preparations. In this study, effects of three bile salts (sodium ursodesoxycholate, sodium chenodesoxycholate and sodium dehydrocholate) on the lipase activity of digestive enzyme preparations were examined. When soybean oil emulsified by polyvinyl alcohol was used as a substrate, these bile salts increased their lipase activity. In the presence of sodium chenodesoxycholate, sodium ursodesoxycholate and sodium dehydrocholate, digestive enzyme preparations increased their lipase activity by 2.2, 1.5 and 1.3 times, respectively, stronger than that in the absence of these bile salts. When soybean oil was used as a substrate, only sodium chenodesoxycholate increased the lipase activity.
日本医療薬学会の論文
1981-12-20