Ecophysiology of the Oral Opportunistic Pathogen Actinobacillus actinomycetemcomitans with Special Emphasis on Leukotoxin Production
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概要
- 論文の詳細を見る
Actinobacillus actinomycetemcomitans, a Gram-negative periodontopathic bacterium, produces a leukotoxin belonging to the RTX family. The leukotoxin determinant consists of four contiguous genes designated ltxC, ltxA, ltxB and ltxD. Although the ltx operon appears to be present in all A. actinomycetemcomitans strains, the level of toxin expression varies considerably between the strains. Several molecular genetic studies have indicated that the difference in leukotoxin production among strains was dependent on the structure of the leukotoxin promoter region. In addition, chemostat culture studies revealed that the production of leukotoxin was influenced greatly by various environmental factors, e.g. growth rate, oxygen, bicarbonate, external sugar level, and pH. In this paper, the state of knowledge of leukotoxin expression in A actinomycetemcomitans is reviewed.
- 日本微生物生態学会の論文
著者
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Ohta Hiroyuki
Department Of Biological Sciences Graduate School Of Bioscience And Biotechnology Tokyo Institute Of
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Ushiba Yuuji
Department Of Bioresource Science College Of Agriculture Ibaraki University
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Ushiba Yuuji
Department Ofbioresource Science Ibaraki University College Of Agriculture
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Ohta Hiroyuki
Department Ofbioresource Science Ibaraki University College Of Agriculture
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