点眼液の防腐剤としての塩化ベンザルコニウムの抗菌力についての検討

概要

論文の詳細を見る
Benzalkonium chloride is most commonly used as a preservative for ophthalmic solutions at a dosage of 50μg/mL. In this study, we evaluated the antibacterial activity of this preservative against 16 species and 64 clinically isolated strains. Benzalkonium chloride demonstrated a good effect on gram-positive cocci, the mini-mum inhibitory concentrations (MIC_s) of benzalkonium chloride to Staphylococcus epidermidis and Staphylococcus aureus including MRSA were less than 12. 5μg/mL. On the other hand, benzalkonium chloride was not effective against gram-negative rods; 95% (42/44) of gram-negative rods strains were not susceptible after treatment with 50μg/mL of benzalkonium chloride. Especially, the MIC_s of benzalkonium chloride to clinically isolated pseudomonas aemginosa were over 200μg/mL. These results suggest that benzalkonium chloride as preservative for ophthalmic solutions in effective on gram-positive cocci even when used in concentrations only one fourth times as much as those commercially available and to gram-negative rods when used in concentrations which may cause damage to the corneas. The use of lower concentration of benzalkonium chloride may therefore make it possible to reduce the degree of damage to the cellular components of the cornea.
日本医療薬学会の論文
2003-06-10