HPN用高カロリー輸液製剤の処方設計 : インスリン添加時の残存率の長期試験と患者の血糖コントロール

概要

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After adding insulin into high-calorie infusion, we measured the residual ratio of insulin which had been administrated daily until the 7 th day, and analyzed the blood sugar levels of the patients. As a consequence, insulin, adsorption to infusion bags, infusion lines, and final filters decreased the residual ratio, which had become stable under saturation and these findings correlated with those from earlier reports. However, following the 3 rd day, due to a decrease in daily insulin titer, a decrease in the residual ratio was again noticed. On the 7 th day, the residual ratio in the drop of both the multiple vitamin added group and nonadded group was 77.9±4.6% and 73.7±5.9%, respectively. On the other hand, the blood sugar level of patients tended to increase according to the dates before administration. Furthermore, an inverse correlation was found between the blood sugar level and the residual ratio of insulin, which thus suggested the possibility that a decrease in the residual ratio of insulin accompanied a daily increase in the blood sugar level of the patients, which thus results insufficient blood sugar control. Therefore, when adding insulin into high-calorie infusions, a daily analysis of the residual ratio, as well as improvements in the TPN (total parenteral nutrition) design, such as a gradual increase in the amounts according to the date of administration, are thought to be requited.
日本医療薬学会の論文
2002-04-10